VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Evidence-based Complementary and Alternative Medicine (2022) 2022:
DOI: 10.1155/2022/6807700
Acute kidney injury (AKI) is a complex condition which has an intricate pathology mostly involving hemodynamic, inflammatory, and direct toxic effects at the cellular level with high morbidity and mortality ratios. Renal ischemic reperfusion injury (RIRI) is the main factor responsible for AKI, most often observed in different types of shock, kidney transplantation, sepsis, and postoperative procedures. The RIRI-induced AKI is accompanied by increased reactive oxygen species generation together with the activation of various inflammatory pathways. In this context, plant-derived medicines have shown encouraging nephroprotective properties. Evidence provided in this systemic review leads to the conclusion that plant-derived extracts and compounds exhibit nephroprotective action against renal ischemic reperfusion induced-AKI by increasing endogenous antioxidants and decreasing anti-inflammatory cytokines. However, there is no defined biomarker or target which can be used for treating AKI completely. These plant-derived extracts and compounds are only tested in selected transgenic animal models. To develop the results obtained into a therapeutic entity, one should apply them in proper vertebrate multitransgenic animal models prior to further validation in humans.
Ali, A., Sampaio, T. L., Haroon Khan, Jeandet, P., Akkol, E. K., Bahadar, H., & Martins, A. M. C. (2022). Plants with therapeutic potential for ischemic acute kidney injury: a systematic review. Evidence-Based Complementary and Alternative Medicine, 2022(6807700). https://doi.org/10.1155/2022/6807700 cytokines, inflammation, reviews, animal models, Acute Kidney Injury, chemical composition, kidney diseases, medicinal plants, kidneys, plant composition, plant extracts, antiinflammatory properties, antioxidant properties, reactive oxygen species, Kidney