VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Animals (2021) 11:
DOI: 10.3390/ani11030715
The main objectives of this study were to perform a systematic review of genomic regions associated with various behavioral traits in the main farmed mammals and identify key candidate genes and potential causal mutations by contrasting the frequency of polymorphisms in cattle breeds with divergent behavioral traits (based on a subjective clustering approach). A total of 687 (cattle), 1391 (pigs), and 148 (sheep) genomic regions associated with 37 (cattle), 55 (pigs), and 22 (sheep) behavioral traits were identified in the literature. In total, 383, 317, and 15 genes overlap with genomic regions identified for cattle, pigs, and sheep, respectively. Six common genes (e.g., NR3C2, PITPNM3, RERG, SPNS3, U6, and ZFAT) were found for cattle and pigs. A combined gene-set of 634 human genes was produced through identified homologous genes. A total of 313 out of 634 genes have previously been associated with behavioral, mental, and neurologic disorders (e.g., anxiety and schizophrenia) in humans. Additionally, a total of 491 candidate genes had at least one statistically significant polymorphism (p-value \textless 0.05). Out of those, 110 genes were defined as having polymorphic regions differing in greater than 50% of exon regions. Therefore, conserved genomic regions controlling behavior were found across farmed mammal species and humans.
Alvarenga, A. B., Oliveira, H. R., Chen, S. Y., Miller, S. P., Marchant-Forde, J. N., Grigoletto, L., & Brito, L. F. (2021). A systematic review of genomic regions and candidate genes underlying behavioral traits in farmed mammals and their link with human disorders. Animals, 11(3). https://doi.org/10.3390/ani11030715 animal behavior, animal behaviour, behavior, hogs, mammals, pigs, swine, cattle, Animal Genetics and Breeding [LL240], traits, man, systematic reviews, Non-communicable Diseases and Injuries of Animals [LL860], Animal Behaviour [LL300], goals, objectives, targets, comparisons, human diseases, sheep, domestic animals, livestock, genes, breeds, genome analysis, animal breed, animal breeds, Non-communicable Human Diseases and Injuries [VV600], cattle breeds, anxiety, Molecular Biology and Molecular Genetics [ZZ360], nervous system diseases, neuropathy, genetic polymorphism, mutations, polymorphism, Taxonomy and Evolution [ZZ380], gene frequency, linkage, regions, schizophrenia