Can resveratrol treatment control the progression of induced periodontal disease? A systematic review and meta-analysis of preclinical studies

Andrade, E. F. and Orlando, D. R. and Araujo, A. M. S. and Andrade, J. N. B. M. de and Azzi, D. V. and Lima, R. R. de and Lobo Junior, A. R. and Pereira, L. J.

Nutrients (2019) 11:

DOI: 10.3390/nu11050953

Abstract

Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following search terms: "resveratrol" OR "3,5,4’-trihydroxystilbene" AND "periodontal disease" OR "periodontitis" OR "gingivitis". Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (T^\textrm2=0.0041; 95% CI: -0.14; -0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5+or-2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression.

Citation

Andrade, E. F., Orlando, D. R., Araujo, A. M. S., Andrade, J. N. B. M. de, Azzi, D. V., Lima, R. R. de, Lobo Junior, A. R., & Pereira, L. J. (2019). Can resveratrol treatment control the progression of induced periodontal disease? A systematic review and meta-analysis of preclinical studies. Nutrients, 11(5). https://doi.org/10.3390/nu11050953 inflammation, meta-analysis, animal models, effects, man, systematic reviews, data analysis, guidelines, health, recommendations, research, studies, Food Science and Food Products (Human) [QQ000], models, human diseases, Information and Documentation [CC300], infections, databases, assessment, food, risk, foods, bones, phytochemicals, data banks, Other Produce [QQ070], animal experiments, animal research, resveratrol, periodontitis, Animal Models of Human Diseases [VV400], Protozoan, Helminth and Arthropod Parasites of Humans [VV220], Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210], mouth diseases, Animal Models of Human Nutrition [VV140], bone destruction, bone resorption, functional foods, mouth, oral health, oral hygiene, periodontal diseases, quality assurance, quality controls, stilbenes, stilbenoids, systemic diseases

Keywords

• inflammation
• meta-analysis
• animal models
• effects
• man
• systematic reviews
• data analysis
• guidelines
• health
• recommendations
• research
• studies
• Food Science and Food Products (Human) [QQ000]
• models
• human diseases
• Information and Documentation [CC300]
• infections
• databases
• assessment
• food
• risk
• foods
• bones
• phytochemicals
• data banks
• Other Produce [QQ070]
• animal experiments
• animal research
• resveratrol
• periodontitis
• Animal Models of Human Diseases [VV400]
• Protozoan
• Helminth and Arthropod Parasites of Humans [VV220]
• Prion
• Viral
• Bacterial and Fungal Pathogens of Humans [VV210]
• mouth diseases
• Animal Models of Human Nutrition [VV140]
• bone destruction
• bone resorption
• functional foods
• mouth
• oral health
• oral hygiene
• periodontal diseases
• quality assurance
• quality controls
• stilbenes
• stilbenoids
• systemic diseases