Genes conferring resistance to critically important antimicrobials in Salmonella enterica isolated from animals and food: A systematic review of the literature, 2013-2017

Antonelli, P. and Belluco, S. and Mancin, M. and Losasso, C. and Ricci, A.

Res Vet Sci (2019) 126: 59–67

DOI: 10.1016/j.rvsc.2019.08.022

Abstract

Antimicrobial resistance is a major public health concern, and food systems are a crucial point in the epidemiology of these resistances. Among antimicrobials, critically important ones are therapeutic drugs that should be primarily safeguarded to allow successful outcomes against important bacterial infections in humans. The most important source of antimicrobial resistance has been recognized in the inappropriate use of antimicrobials in human and animal medicine, with farming being a critical stage. Products of animal origin are the link between animal and humans and can contribute to the spread of antimicrobial resistance, in particular through bacteria such as Enterobacteriaceae, commonly present in both animals’ gut and food. Salmonella is an important member of this bacterial family due to its pathogenicity, its noteworthy prevalence and the frequent detection of resistance genes in different isolates. In the present systematic review, the distribution of antimicrobial resistance determinants among Salmonella enterica serovars in pigs, cattle and poultry production was investigated in the European context. A comprehensive literature search was carried out in three different databases, and 7955 papers were identified as relevant. After the different steps of the review process, 31 papers were considered eligible for data extraction to gain insight about sources and reservoirs for such genes. Results suggest that despite the increasing attention directed toward antimicrobial resistance in animal production, a wide plethora of genes still exist and further actions should be undertaken to face this challenge.

Citation

Antonelli, P., Belluco, S., Mancin, M., Losasso, C., & Ricci, A. (2019). Genes conferring resistance to critically important antimicrobials in Salmonella enterica isolated from animals and food: A systematic review of the literature, 2013-2017. Res Vet Sci, 126, 59–67. https://doi.org/10.1016/j.rvsc.2019.08.022 Animals, Humans, Food safety, Epidemiology, *Food Microbiology, Food chain, *Drug Resistance, Multiple, Bacterial, AMR genes, Anti-Bacterial Agents/*pharmacology, Lactamase, Salmonella enterica/drug effects/*genetics/*isolation & purification, Salmonella Infections, Animal/*microbiology

Keywords

• Animals
• Humans
• Food safety
• Epidemiology
• *Food Microbiology
• Food chain
• *Drug Resistance
• Multiple
• Bacterial
• AMR genes
• Anti-Bacterial Agents/*pharmacology
• Lactamase
• Salmonella enterica/drug effects/*genetics/*isolation & purification
• Salmonella Infections
• Animal/*microbiology