Seroprevalence of Neospora caninum Infection in Dog Population Worldwide: A Systematic Review and Meta-analysis

Anvari, D. and Saberi, R. and Sharif, M. and Sarvi, S. and Hosseini, S. A. and Moosazadeh, M. and Hosseininejad, Z. and Chegeni, T. N. and Daryani, A.

Acta Parasitol (2020) 65: 273–290

DOI: 10.2478/s11686-019-00163-4

Abstract

PURPOSE: Neospora caninum is an obligate intracellular apicomplexan protozoan that causes neurological disorders in dogs. This systematic review and meta-analysis targeted at evaluating the worldwide seroprevalence rate of N. caninum in dogs. METHODS: Five electronic databases, including PubMed, Scopus, Web of Science, Science Direct, and Google Scholar, until December 2018 were thoroughly searched for relevant English language articles. Papers were selected based on inclusion criteria. Data were analyzed in StatsDirect statistical software (version 2.7.9). RESULTS: The searching process yielded a total number of 156 papers. The total prevalence (95% confidence intervals) of N. caninum infection in dog population worldwide was measured as 17.14% in data analyses (15.25-19.10). In addition, a significant association was also detected between neosporosis infection in dogs and continent, country, year, WHO regions, sample size and diagnostic method (P \textless 0.001). CONCLUSION: Dogs are a matter of concern to public health officials as a source of N. caninum infection. Therefore, it is of paramount importance to provide comprehensive data and systematically analyze the prevalence of N. caninum infection in dogs. Accordingly, it is recommended that researchers carry out further studies to prevent and control neosporosis among dog population worldwide.

Citation

Anvari, D., Saberi, R., Sharif, M., Sarvi, S., Hosseini, S. A., Moosazadeh, M., Hosseininejad, Z., Chegeni, T. N., & Daryani, A. (2020). Seroprevalence of Neospora caninum Infection in Dog Population Worldwide: A Systematic Review and Meta-analysis. Acta Parasitol, 65(2), 273–290. https://doi.org/10.2478/s11686-019-00163-4 Animals, Dogs, Global Health, Seroepidemiologic Studies, Meta-analysis, Systematic review, Antibodies, Protozoan/*blood, Coccidiosis/epidemiology/parasitology/*veterinary, Dog Diseases/*epidemiology/*parasitology, Neospora caninum, Neospora/*immunology, Neosporosis

Keywords

• Animals
• Dogs
• Global Health
• Seroepidemiologic Studies
• Meta-analysis
• Systematic review
• Antibodies
• Protozoan/*blood
• Coccidiosis/epidemiology/parasitology/*veterinary
• Dog Diseases/*epidemiology/*parasitology
• Neospora caninum
• Neospora/*immunology
• Neosporosis