The association between diazinon exposure and dyslipidemia occurrence: a systematic and meta-analysis study

Aramjoo, H. and Farkhondeh, T. and Aschner, M. and Naseri, K. and Mehrpour, O. and Sadighara, P. and Roshanravan, B. and Samarghandian, S.

Environmental Science and Pollution Research (2021) 28: 3994–4006

DOI: 10.1007/s11356-020-11363-1

Abstract

The effects of diazinon (DZN), an organophosphate pesticide, on lipid profiles have been extensively reported. However, controversy on this issue persists. Here, we performed a systematic and meta-analysis study to investigate the association between DZN exposure and dyslipidemia in rodents and fish species. This systematic review was prepared according to the PRISMA guidelines. Main databases, including Google Scholar, Scopus, PubMed, Ovid MEDLINE, and Web of Science, were systematically searched through March 4, 2020. The risk of bias was evaluated with the SYRCLE’s RoB tool. Once all articles were assessed for scientific quality, a random-effects model was applied to perform a pooled analysis. I^\textrm2 and Q test were used to assess the heterogeneity between articles, and Forest plots, indicating point and pooled estimates, were drawn. Twenty-eight articles were included; between them, 13 publications were selected for meta-analysis. Random-effects meta-analysis showed low heterogeneity between the articles. A pooled analysis indicated that DZN significantly increased total cholesterol levels (95% CI: 0.86-3.79; Z = 3.10; p = 0.002), triglyceride (95% CI: 0.38-3.22; Z = 2.48; p = 0.09), low-density lipoprotein cholesterol (95% CI: 0.25-2.85; Z = 2.34; p = 0.7) in the DZN vs. control groups. In addition, DZN significantly decreased high-density lipoprotein cholesterol (95% CI: - 2.92, - 0.42; Z = 2.62; p = 0.07) in the DZN vs. control groups. No publication bias was observed. Our findings suggest that DZN induces dyslipidemia in rodents and fish species in a dose-dependent manner.

Citation

Aramjoo, H., Farkhondeh, T., Aschner, M., Naseri, K., Mehrpour, O., Sadighara, P., Roshanravan, B., & Samarghandian, S. (2021). The association between diazinon exposure and dyslipidemia occurrence: a systematic and meta-analysis study. Environmental Science and Pollution Research, 28(4), 3994–4006. https://doi.org/10.1007/s11356-020-11363-1 animal models, Animal Models of Human Diseases [VV400], aquatic animals, aquatic organisms, aquatic species, cholesterol, diazinon, exposure, fat metabolism, fat metabolism disorders, fishes, guidelines, high density lipoprotein, human diseases, lipaemia, lipemia, lipid metabolism, lipid metabolism disorders, low density lipoprotein, meta-analysis, Non-communicable Human Diseases and Injuries [VV600], organophosphorus pesticides, Pesticide and Drug Residues and Ecotoxicology [HH430], pesticides, recommendations, relationships, rodents, systematic reviews, triacylglycerols, triglycerides

Keywords

• animal models
• Animal Models of Human Diseases [VV400]
• aquatic animals
• aquatic organisms
• aquatic species
• cholesterol
• diazinon
• exposure
• fat metabolism
• fat metabolism disorders
• fishes
• guidelines
• high density lipoprotein
• human diseases
• lipaemia
• lipemia
• lipid metabolism
• lipid metabolism disorders
• low density lipoprotein
• meta-analysis
• Non-communicable Human Diseases and Injuries [VV600]
• organophosphorus pesticides
• Pesticide and Drug Residues and Ecotoxicology [HH430]
• pesticides
• recommendations
• relationships
• rodents
• systematic reviews
• triacylglycerols
• triglycerides