In vitro lytic efficiency of Staphylococcus aureus bacteriophages in bacteria from bovine mastitis: a meta-analysis

Barasuol, B. M. and Ely, V. L. and Matos, A. F. I. M. de and Sangioni, L. A. and Vargas, A. C. de and Pereira, D. I. B. and Martini, A. C. and Potter, L. and Botton, S. de A.

Ciencia Rural (2021) 51:

DOI: 10.1590/0103-8478cr20200839

Abstract

Bacteriophages have been investigated as alternative to the treatment of bacterial infections, including bovine mastitis, in production animals. In this meta-analysis, we evaluated in vitro efficiency of phages of Staphylococcus aureus against S. aureus, which is involved in the etiology of bovine mastitis. Seventeen studies were included and the bacterial lytic activity was extracted using proportion analysis. The lytic efficiency of phages was obtained in this meta-analysis using a random-effects model [significant difference (P\textless0.05)]. Forest plots were used to graphically represent the efficiency of phages on bacterial isolates. Most phages (e.g., CS1, DW2, SA011, SA012, SA022, SA023, SA024, SA025, SA037, SA038, SA039, SA041, SA042, SA043, SA044, MSA6, Ufv-aur2 to Ufv-aur11, SAH-1, SPW, vB_SauM_JS25, SaPh1 to SaPh6, SA, SANF, SA2, SA012, SA039, phi11, phiIPLA88, phiIPLA35, phiIPLA-RODI, phiIPLA-C1C, SAJK-IND, vBSP-A1, vBSP-A2, STA1. ST29, EB1. ST11, EB1. ST27, Remus, and ISP) were efficiently lytics or infected most S. aureus isolates, demonstrating 80% (P\textless0.05) lytic efficiency. The phages SA, SANF and SA2, also demonstrated lytic activity or infected the non-Staphylococcus aureus and Macrococcus caseolyticus isolates. In this meta-analysis, we compared and demonstrated the in vitro efficiency and host range of S. aureus phages. Additionally, the phages represent an alternative to be researched to treat bovine mastitis in dairy cattle caused by the prevalent microorganism, S. aureus.

Citation

Barasuol, B. M., Ely, V. L., Matos, A. F. I. M. de, Sangioni, L. A., Vargas, A. C. de, Pereira, D. I. B., Martini, A. C., Potter, L., & Botton, S. de A. (2021). In vitro lytic efficiency of Staphylococcus aureus bacteriophages in bacteria from bovine mastitis: a meta-analysis. Ciencia Rural, 51(10). https://doi.org/10.1590/0103-8478cr20200839 bovine mastitis, cattle, cows, dairy cattle, dairy cows, meta-analysis, therapeutics, therapy, Dairy Animals [LL110], Mathematics and Statistics [ZZ100], data analysis, research, studies, in vitro, bacterium, infections, bacterial diseases, Staphylococcus, Staphylococcus aureus, viruses, bacterial infections, bacterioses, Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821], mastitis, Biochemistry and Physiology of Microorganisms [ZZ394], efficiency, natural enemies, bacteriophages, biocontrol, biocontrol agents, biological control, Biological Control [HH100], biological control agents, biological control organisms, Macrococcus, Macrococcus caseolyticus, mammillitis, phages, teat diseases, thelitis

Keywords

• bovine mastitis
• cattle
• cows
• dairy cattle
• dairy cows
• meta-analysis
• therapeutics
• therapy
• Dairy Animals [LL110]
• Mathematics and Statistics [ZZ100]
• data analysis
• research
• studies
• in vitro
• bacterium
• infections
• bacterial diseases
• Staphylococcus
• Staphylococcus aureus
• viruses
• bacterial infections
• bacterioses
• Prion
• Viral
• Bacterial and Fungal Pathogens of Animals [LL821]
• mastitis
• Biochemistry and Physiology of Microorganisms [ZZ394]
• efficiency
• natural enemies
• bacteriophages
• biocontrol
• biocontrol agents
• biological control
• Biological Control [HH100]
• biological control agents
• biological control organisms
• Macrococcus
• Macrococcus caseolyticus
• mammillitis
• phages
• teat diseases
• thelitis