Systematic evaluation of evidence on veterinary viscoelastic testing Part 5: Nonstandard assays

Brainard, B M and Goggs, R and Mendez-Angulo, J L and Mudge, M C and Ralph, A G and Wiinberg, B

Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001) (2014) 24: 57–62

DOI: 10.1111/vec.12146

Abstract

OBJECTIVE: To systematically examine the evidence on nontraditional uses of viscoelastic coagulation monitoring in veterinary species. DESIGN: Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical practice. SETTING: Academic and referral veterinary medical centers. RESULTS: Databases searched included Medline, CAB abstracts, and Google Scholar. CONCLUSIONS: Nontraditional assays identified included thrombelastography (TEG)-PlateletMapping (PM), functional fibrinogen assessment, and rapid-TEG (r-TEG). Direct veterinary evidence was found for only the ADP-activated PM, which appears to generate valid data in dogs but not cats or horses. Arachidonic acid activated PM shows high variability and requires further assessment and validation in veterinary species. Functional fibrinogen assays may be performed in veterinary species but may require modification due to species differences in response to abciximab. While tissue factor (TF)-activated TEG has been well described in the veterinary literature, the specific r-TEG assay has not been assessed, but presumably would be effective for generating TEG tracings and values for maximum amplitude and angle in shorter periods of time than some traditional assays.

Citation

Brainard, B. M., Goggs, R., Mendez-Angulo, J. L., Mudge, M. C., Ralph, A. G., & Wiinberg, B. (2014). Systematic evaluation of evidence on veterinary viscoelastic testing Part 5: Nonstandard assays. Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), 24(1), 57–62. https://doi.org/10.1111/vec.12146 Animals, Dogs, Cats, Blood Specimen Collection/methods, Blood Specimen Collection/standards, Blood Specimen Collection/veterinary, Cats/blood, Dogs/blood, Horses, Horses/blood, Reference Standards, Thrombelastography/instrumentation, Thrombelastography/methods, Thrombelastography/veterinary, Veterinary Medicine/standards

Keywords

• Animals
• Dogs
• Cats
• Blood Specimen Collection/methods
• Blood Specimen Collection/standards
• Blood Specimen Collection/veterinary
• Cats/blood
• Dogs/blood
• Horses
• Horses/blood
• Reference Standards
• Thrombelastography/instrumentation
• Thrombelastography/methods
• Thrombelastography/veterinary
• Veterinary Medicine/standards