VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Amino Acids (2018) 50: 1663–1678
DOI: 10.1007/s00726-018-2658-8
L-Leucine has been used to improve metabolic outcomes in glucose-intolerant rodent models. However, because studies have used different experimental models and conditions it is difficult to establish the best approach for new clinical trials evaluating the potential effects of L-leucine on glucose homeostasis. We performed a systematic review to report the effect of L-leucine supplementation on glucose homeostasis in rodents with glucose intolerance. The search engines MEDLINE and ScienceDirect were applied using MeSH terms. Thirty-four studies were included in this systematic review. Based on the current data, ingestion of 90-140 mg day(-1) of isolated L-leucine in diet-induced obesity (DIO) models shows improvement in metabolic markers if offered during the development of the metabolic disorder in almost all the studies, but not after. Branched-chain amino acid supplementation was effective in streptozotocin-induced β-cells death but not in DIO models. L-Leucine supplementation seems to have an optimal dose and timing for supplementation to improve glucose homeostasis in DIO.
Brunetta, H. S., de Camargo, C. Q., & Nunes, E. A. (2018). Does L-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review. Amino Acids, 50(12), 1663–1678. https://doi.org/10.1007/s00726-018-2658-8 Animals, Disease Models, Animal, Humans, Insulin/metabolism, Diabetes, Rodentia, *Dietary Supplements, Insulin resistance, Mice, Obese, Obesity, Blood Glucose/*drug effects, Diabetes Mellitus, Type 2/prevention & control, Glucose homeostasis, Glucose Intolerance/*diet therapy, Homeostasis/*drug effects, Leucine, Leucine/*administration & dosage/pharmacology, Obesity/diet therapy