VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Zoonoses and Public Health (2018) 65: e162–e184
DOI: 10.1111/zph.12426
Point sources such as wastewater treatment plants and agricultural facilities may have a role in the dissemination of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARG). To analyse the evidence for increases in ARB in the natural environment associated with these point sources of ARB and ARG, we conducted a systematic review. We evaluated 5,247 records retrieved through database searches, including both studies that ascertained ARG and ARB outcomes. All studies were subjected to a screening process to assess relevance to the question and methodology to address our review question. A risk of bias assessment was conducted upon the final pool of studies included in the review. This article summarizes the evidence only for those studies with ARB outcomes (n=47). Thirty-five studies were at high (n=11) or at unclear (n=24) risk of bias in the estimation of source effects due to lack of information and/or failure to control for confounders. Statistical analysis was used in ten studies, of which one assessed the effect of multiple sources using modelling approaches; none reported effect measures. Most studies reported higher ARB prevalence or concentration downstream/near the source. However, this evidence was primarily descriptive and it could not be concluded that there is a clear impact of point sources on increases in ARB in the environment. To quantify increases in ARB in the environment due to specific point sources, there is a need for studies that stress study design, control of biases and analytical tools to provide effect measure estimates.
Bueno, I., Williams-Nguyen, J., Hwang, H., Sargeant, J. M., Nault, A. J., & Singer, R. S. (2018). Impact of point sources on antibiotic-resistant bacteria in the natural environment. Zoonoses and Public Health, 65(1), e162–e184. https://doi.org/10.1111/zph.12426 effects, methodology, methods, techniques, Techniques and Methodology [ZZ900], systematic reviews, Mathematics and Statistics [ZZ100], statistical analysis, statistical methods, research, studies, models, plants, estimation, Bacteria, bacterium, drug resistance, Pesticide and Drug Resistance [HH410], zoonoses, zoonotic infections, Information and Documentation [CC300], genes, control, databases, screening, data banks, antibiotics, *systematic review, waste water, wastewater, incidence, Pesticides and Drugs, Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821], Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210], Control [HH405], Environmental Pollutants, screening tests, Pathogens, Parasites and Infectious Diseases (Wild Animals) [YY700], *Environmental Microbiology, Drug Resistance, Bacterial/*genetics, *antibiotic-resistant bacteria, *effect measure, *environmental dissemination, *point source, Agricultural and Forestry Equipment (General) [NN400], Anti-Bacterial Agents/chemistry/*pharmacology, Bacteria/*drug effects/*genetics, Processing Equipment and Technology [NN600], treatment plants, waste water treatment, waste-water treatment, Wastes (General) [XX000], wastewater treatment