Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies

Bule, M. and Abdurahman, A. and Nikfar, S. and Abdollahi, M. and Amini, M.

Food Chem Toxicol (2019) 125: 494–502

DOI: 10.1016/j.fct.2019.01.037

Abstract

Quercetin is a plant polyphenol with biological activities such as anti-inflammatory, anticancer, antidiabetic, neuroprotective and anti-allergic. The objective of this review is to provide a systematic evaluation of the evidence and a meta-analysis of data from previously published researches on the antidiabetic action of quercetin. A comprehensive literature search was conducted between July 2018 and August 2018 on PubMed, EMBASE, Web of Sciences and Scopus databases. A random-effects model was used to estimate the pooled effect size and studies were weighted according to an estimate of the mean difference. The heterogeneity between studies was assessed using a Higgins’ I2 test with corresponding p values. Overall 13 eligible articles with appropriate data on serum glucose were included in the statistical analysis. The meta-analysis for serum glucose level (mg/dL) showed that at doses of 10, 25 and 50 mg/kg there was a significant difference between the means. Therefore, the results of the meta-analysis support the hypothesis that quercetin lowers serum glucose level, at doses of 10, 25 and 50 mg/kg.

Citation

Bule, M., Abdurahman, A., Nikfar, S., Abdollahi, M., & Amini, M. (2019). Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies. Food Chem Toxicol, 125, 494–502. https://doi.org/10.1016/j.fct.2019.01.037 Animals, Dose-Response Relationship, Drug, Hypoglycemic Agents/*pharmacology, Diabetes, Meta-analysis, Systematic review, Quercetin/*pharmacology, Blood Glucose/analysis, Quercetin, Flavonoids

Keywords

• Animals
• Dose-Response Relationship
• Drug
• Hypoglycemic Agents/*pharmacology
• Diabetes
• Meta-analysis
• Systematic review
• Quercetin/*pharmacology
• Blood Glucose/analysis
• Quercetin
• Flavonoids