Antibiotic susceptibility among non-clinical Escherichia coli as a marker of antibiotic pressure in Peru (2009-2019): one health approach

Castillo, A. K. and Espinoza, K. and Chaves, A. F. and Guibert, F. and Ruiz, J. and Pons, M. J.

Special Issue: Microbiology. (2022) 8:

DOI: 10.1016/j.heliyon.2022.e10573

Abstract

Objective: Antimicrobial resistance is an increasing health problem worldwide with serious implications in global health. The overuse and misuse of antimicrobials has resulted in the spread of antimicrobial-resistant microorganisms in humans, animals and the environment. Surveillance of antimicrobial resistance provides important information contributing to understanding dissemination within these environments. These data are often unavailable in low- and middle-income countries, such as Peru. This review aimed to determine the levels of antimicrobial resistance in non-clinical Escherichia coli beyond the clinical setting in Peru. Methods: We searched 2009-2019 literature in PUBMED, Google Scholar and local repositories. Results: Thirty manuscripts including human, food, environmental, livestock, pets and/or wild animals’ samples were found. The analysis showed high resistance levels to a variety of antimicrobial agents, with \textgreater90% of resistance for streptomycin and non-extended-spectrum cephalosporin in livestock and food. High levels of rifamycin resistance were also found in non-clinical samples from humans. In pets, resistance levels of 70-\textgreater90% were detected for quinolones tetracycline and non-extended spectrum cephalosporins. The results suggest higher levels of antimicrobial resistance in captive than in free-ranging wild-animals. Finally, among environmental samples, 50-70% of resistance to non-extended-spectrum cephalosporin and streptomycin was found. Conclusions: High levels of resistance, especially related to old antibacterial agents, such as streptomycin, 1st and 2nd generation cephalosporins, tetracyclines or first-generation quinolones were detected. Antimicrobial use and control measures are needed with a One Health approach to identify the main drivers of antimicrobial resistance due to interconnected human, animal and environmental habitats.

Citation

Castillo, A. K., Espinoza, K., Chaves, A. F., Guibert, F., Ruiz, J., & Pons, M. J. (2022). Antibiotic susceptibility among non-clinical Escherichia coli as a marker of antibiotic pressure in Peru (2009-2019): one health approach. Special Issue: Microbiology., 8(9). https://doi.org/10.1016/j.heliyon.2022.e10573 pets, drug resistance, human diseases, publications, domestic animals, livestock, animal diseases, databases, internet, web sites, antibacterial agents, antibiotics, beta-lactam antibiotics, cephalosporins, tetracycline, tetracyclines, Escherichia coli, Anti-Bacterial Agents, antibiotic resistance, drug susceptibility, aminoglycoside antibiotics, multiple drug resistance, biological markers, information systems, on line, resistance mechanisms, quinolones, rifamycin, streptomycin

Keywords

• pets
• drug resistance
• human diseases
• publications
• domestic animals
• livestock
• animal diseases
• databases
• internet
• web sites
• antibacterial agents
• antibiotics
• beta-lactam antibiotics
• cephalosporins
• tetracycline
• tetracyclines
• Escherichia coli
• Anti-Bacterial Agents
• antibiotic resistance
• drug susceptibility
• aminoglycoside antibiotics
• multiple drug resistance
• biological markers
• information systems
• on line
• resistance mechanisms
• quinolones
• rifamycin
• streptomycin