Efficacy of oral consumption of curcumin/ for symptom improvement in inflammatory bowel disease: a systematic review of animal models and a meta-analysis of randomized clinical trials

Cerqueira Alves, M. de and Santos, M. O. and Bueno, N. B. and Araujo, O. R. P. de and Goulart, M. O. F. and Moura, F. A.

Biocell (2022) 46: 2015–2047

DOI: 10.32604/biocell.2022.020407

Abstract

The roots of the vegetal Curcuma due to its high content of polyphenols, has been used successfully in several clinical situations. This review assessed the effect of curcumin/Curcuma longa on symptoms and metabolic changes in inflammatory bowel disease (IBD). A systematic review of animal models and randomized clinical trials (RCTs) was conducted by searching the following electronic databases: PubMed, CENTRAL, LILACS, Science Direct, and ClinicalTrials.gov. From 997 found records, 62 were included. More than 90% of the animal studies reported an improvement in macroscopic, histologic and/or functional activity; 80% identified decreased oxidative and/or inflammatory biomarkers in animals treated with curcumin. Among the RCTs, intention-to-treat analysis showed that oral curcumin was effective in inducing clinical remission (n = 281, RR: 3.15 CI 95% [1.22-8.10] p = 0.0017; i2 = 72.2%, p = 0.006) and clinical response (n = 259, RR: 1.60 CI 95% [1.09-2.35] p = 0.0017; i2 = 59.7%, p = 0.042) but not endoscopic remission (n = 161, RR: 2.91 CI 95% [0.58-14.58] p = 0.195; i2 = 72.7%, p = 0.026). These results confirm that oral supplementation with curcumin/Curcuma longa has beneficial actions in animal colitis and, when associated with drug therapy, is effective in the treatment of patients with IBD.

Citation

Cerqueira Alves, M. de, Santos, M. O., Bueno, N. B., Araujo, O. R. P. de, Goulart, M. O. F., & Moura, F. A. (2022). Efficacy of oral consumption of curcumin/ for symptom improvement in inflammatory bowel disease: a systematic review of animal models and a meta-analysis of randomized clinical trials. Biocell, 46(9), 2015–2047. https://doi.org/10.32604/biocell.2022.020407 Animals, meta-analysis, animal models, systematic reviews, chemical composition, human diseases, biochemical markers, plant composition, plant extracts, databases, antiinflammatory properties, curcumin, phytochemicals, turmeric, clinical trials, inflammatory bowel diseases, symptoms, polyphenols, roots, Animal Shells

Keywords

• Animals
• meta-analysis
• animal models
• systematic reviews
• chemical composition
• human diseases
• biochemical markers
• plant composition
• plant extracts
• databases
• antiinflammatory properties
• curcumin
• phytochemicals
• turmeric
• clinical trials
• inflammatory bowel diseases
• symptoms
• polyphenols
• roots
• Animal Shells