Animals as amplification hosts in the spread of severe fever with thrombocytopenia syndrome virus: A systematic review and meta-analysis

Chen, C. and Li, P. and Li, K. F. and Wang, H. L. and Dai, Y. X. and Cheng, X. and Yan, J. B.

Int J Infect Dis (2019) 79: 77–84

DOI: 10.1016/j.ijid.2018.11.017

Abstract

OBJECTIVES: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV). The seroprevalence of anti-SFTSV antibodies specific to SFTSV (IgG or IgM) has been investigated in different animal hosts in many epidemiological studies, but no systematic estimation of seroprevalence has yet been performed. Hence, this meta-analysis was conducted in order to obtain a more comprehensive result to clarify the prevalence of SFTSV in animals. METHODS: A search for all relevant articles was conducted in the major national and international electronic databases up to August 2018. Data on seroprevalence of SFTSV antibodies (IgM and IgG) were extracted as the primary outcome. The pooled seroprevalence rates and 95% confidence intervals (95% CI) were determined. RESULTS: Overall, anti-SFTSV antibodies (IgG or IgM) were detected in 15 animal species. The pooled seroprevalence of anti-SFTSV antibodies was 45.70% in goats and sheep, 36.70% in cattle, 29.50% in dogs, 9.60% in chickens, 3.20% in rodents, and 3.20% in pigs. The seroprevalence of SFTSV in animals that had a confined range was significantly lower than that in free-range animals. SFTSV RNA was detected in 11 animal species, with a carriage rate varying from 0.23% to 26.31%. CONCLUSIONS: SFTSV has a wide spectrum of animal hosts, including domestic and wild animals. The prevalence of SFTSV is high among specific animal species.

Citation

Chen, C., Li, P., Li, K. F., Wang, H. L., Dai, Y. X., Cheng, X., & Yan, J. B. (2019). Animals as amplification hosts in the spread of severe fever with thrombocytopenia syndrome virus: A systematic review and meta-analysis. Int J Infect Dis, 79, 77–84. https://doi.org/10.1016/j.ijid.2018.11.017 Animals, Chickens, Swine, Cattle, Sheep, Goats, Seroepidemiologic Studies, Meta-analysis, Seroprevalence, Rodentia, Immunoglobulin G/blood, Amplify hosts, Antibodies, Viral/blood, Bunyaviridae Infections/veterinary/*virology, Immunoglobulin M/blood, Phlebovirus/*isolation & purification, Sftsv, Thrombocytopenia/veterinary/*virology

Keywords

• Animals
• Chickens
• Swine
• Cattle
• Sheep
• Goats
• Seroepidemiologic Studies
• Meta-analysis
• Seroprevalence
• Rodentia
• Immunoglobulin G/blood
• Amplify hosts
• Antibodies
• Viral/blood
• Bunyaviridae Infections/veterinary/*virology
• Immunoglobulin M/blood
• Phlebovirus/*isolation & purification
• Sftsv
• Thrombocytopenia/veterinary/*virology