Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Costa, M. F. and Durço, A. O. and Rabelo, T. K. and Barreto, R. S. S. and Guimarães, A. G.

J Pharm Pharmacol (2019) 71: 141–155

DOI: 10.1111/jphp.13054

Abstract

OBJECTIVES: The treatment of wounds accounts for a considerable fraction of health expenses as well as serious socioeconomic problems. The use of natural substances stands out as a source of new therapeutic discoveries for the wound healing. Thus, this review compiled scientific findings on the applicability of carvacrol and thymol, or essential oils containing at least one of these compounds, for the treatment of wounds. METHODS: This review was performed at PubMed, SCOPUS, Web of Science databases using keywords as wound healing, thymol/carvacrol and essential oils. Thirteen studies were selected for discussion. KEY FINDINGS: Thymol/carvacrol was able to act in the three phases of wound healing. In the first phase, they showed modulatory effect of the inflammatory cytokines, oxidative stress and antimicrobial power. In the second phase, they promoted re-epithelialization, angiogenesis and development of granulation tissue. Finally, in the third phase, they improve the collagen deposition and modulated the growth of fibroblasts and keratinocytes. CONCLUSIONS: These compounds present a high potential for the development of new therapeutic for wound repair. However, dose, efficacy and safety of these compounds for the treatment of wounds, as well as the mechanisms by which those effects can be observed, are challenges for future studies.

Citation

Costa, M. F., Durço, A. O., Rabelo, T. K., Barreto, R. S. S., & Guimarães, A. G. (2019). Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review. J Pharm Pharmacol, 71(2), 141–155. https://doi.org/10.1111/jphp.13054 Animals, Humans, Cytokines/metabolism, Oxidative Stress/drug effects, essential oils, wounds, Anti-Infective Agents/pharmacology, wound healing, Wound Healing/*drug effects, Monoterpenes/*pharmacology, carvacrol, Cymenes, Oils, Volatile/*pharmacology, thymol, Thymol/pharmacology

Keywords

• Animals
• Humans
• Cytokines/metabolism
• Oxidative Stress/drug effects
• essential oils
• wounds
• Anti-Infective Agents/pharmacology
• wound healing
• Wound Healing/*drug effects
• Monoterpenes/*pharmacology
• carvacrol
• Cymenes
• Oils
• Volatile/*pharmacology
• thymol
• Thymol/pharmacology