Current evidence of tissue engineering for dentine regeneration in animal models: a systematic review

da Silva, G. S. and Moreira, M. S. and Fukushima, K. A. and Raggio, D. P. and AC, V. Mello-Moura and Lara, J. S. and Gimenez, T. and Junior, S. A. and Morimoto, S. and Tedesco, T. K.

Regen Med (2020) 15: 1345–1360

DOI: 10.2217/rme-2019-0005

Abstract

Aim: The aim of this study is to verify the type of scaffold effect on tissue engineering for dentine regeneration in animal models. Materials & methods: Strategic searches were conducted through MEDLINE/PubMed, Web of Science and Scopus databases. The studies were included with the following eligibility criteria: studies evaluating dentine regeneration, and being an in vivo study. Results: From 1392 identified potentially relevant studies, 15 fulfilled the eligibility criteria. All studies described characteristics of neoformed dentine, being that the most reported reparative dentine formation. Most of included studies presented moderate risk of bias. Conclusion: Up to date scientific evidence shows a positive trend to dentine regeneration when considering tissue engineering in animal models, regardless the type of scaffolds used.

Citation

da Silva, G. S., Moreira, M. S., Fukushima, K. A., Raggio, D. P., AC, V. M.-M., Lara, J. S., Gimenez, T., Junior, S. A., Morimoto, S., & Tedesco, T. K. (2020). Current evidence of tissue engineering for dentine regeneration in animal models: a systematic review. Regen Med, 15(2), 1345–1360. https://doi.org/10.2217/rme-2019-0005 *systematic review, *stem cells, *dental caries, *dental pulp capping, *dentine, *tissue engineering, *tissue scaffolds, *tooth injuries

Keywords

• *systematic review
• *stem cells
• *dental caries
• *dental pulp capping
• *dentine
• *tissue engineering
• *tissue scaffolds
• *tooth injuries