What is the Evidence of Hyaluronic Acid and Polyacrylamide Hydrogel in Intra-articular Therapy in Equines? Systematic Literature Review

de Souza, A. F. and Paretsis, N. F. and De Zoppa, Aldv

J Equine Vet Sci (2020) 86: 102909

DOI: 10.1016/j.jevs.2019.102909

Abstract

A systematic review was conducted to investigate evidence to support or refute the use of hyaluronic acid and polyacrylamide hydrogel as intra-articular therapy in equines, which are frequent treatment options in the routine of veterinarians of equines in cases of osteoarthritis. In total, 19 studies were included, among clinical and in vitro studies, as well as a retrospective series of cases. The outcomes of the included studies provided fragile evidence supporting the recommendation for intra-articular use of hyaluronic acid. No study was included showing any clinical outcome in diseased synovial tissues of the polyacrylamide hydrogel. There is no concrete evidence of benefits, treatment protocols, and mechanisms of action of hyaluronic acid in the joint therapy in equines.

Citation

de Souza, A. F., Paretsis, N. F., & De Zoppa, A. (2020). What is the Evidence of Hyaluronic Acid and Polyacrylamide Hydrogel in Intra-articular Therapy in Equines? Systematic Literature Review. J Equine Vet Sci, 86, 102909. https://doi.org/10.1016/j.jevs.2019.102909 Animals, Retrospective Studies, Horses, *Osteoarthritis, *Acrylic Resins, *Hyaluronic Acid, *Joint, *Lameness, *Viscosupplementation, Injections, Intra-Articular/veterinary

Keywords

• Animals
• Retrospective Studies
• Horses
• *Osteoarthritis
• *Acrylic Resins
• *Hyaluronic Acid
• *Joint
• *Lameness
• *Viscosupplementation
• Injections
• Intra-Articular/veterinary