VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
The British Government spends over \textlesspounds\textgreater100 million per annum on the control of bovine tuberculosis (bTB). Improvement in the control through targeted use of diagnostic tests is one focus of eradication plans. The aims were: (a) through systematic literature review identify primary research with estimates of sensitivity (Se) and specificity (Sp) for diagnostic tests for bTB in cattle (b) conduct a statistical meta-analysis to estimate test performance, and (c) using the estimates, model and compare different testing strategies. Of 9782 references reviewed, only 261 met agreed criteria and contained performance estimates for one or more of 14 diagnostic tests. The performance of bTB surveillance systems using the estimates of test performance was affected by the historical probability of herd freedom and the risk of introduction of infection. Where the probability of introduction of infection was high, it was difficult to achieve a high target probability of herd freedom from infection.
Downs, S. H., Parry, J., Nunez-Garcia, J., Abernethy, D. A., Broughan, J. M., Cameron, A. R., Cook, A. J., Rua-Domenech, R. de la, Goodchild, A. V., Greiner, M., Gunn, J., More, S. J., Rhodes, S., Rolfe, S., Sharp, M., Upton, P., Vordermeier, H. M., Watson, E., Welsh, M., … Clifton-Hadley, R. S. (2011). Meta-analysis of diagnostic test performance and modelling of testing strategies for control of bovine tuberculosis in GB. Society for Veterinary Epidemiology and Preventive Medicine. https://www.researchgate.net/publication/285664854_Meta-analysis_of_diagnostic_test_performance_and_modelling_of_testing_strategies_for_control_of_bovine_tuberculosis [Indexed using CAB Thesaurus terms], animals, Artiodactyla, Chordata, eukaryotes, mammals, ungulates, vertebrates, Bacterial and Fungal Pathogens of Animals [LL821], Bos, Bovidae, cattle, cows, dairy cattle, dairy cows, Diagnosis of Animal Diseases [LL886], disease control, disease prevention, meta-analysis, Prion, ruminants, Viral, Commonwealth of Nations, Developed Countries, OECD Countries, Dairy Animals [LL110], mathematical models, Mathematics and Statistics [ZZ100], statistical analysis, Europe, European Union Countries, Western Europe, disease prevalence, epidemiology, Bacteria, prokaryotes, disease transmission, Mycobacteriaceae, Mycobacterium, Mycobacterium bovis, diagnosis, diagnostic techniques, monitoring, tuberculosis, control programmes, risk, Actinobacteria, Actinobacteridae, Actinomycetales, British Isles, Corynebacterineae, dairy herds, estimates, probability, UK