The prevalence of amphenicol resistance in Escherichia coli isolated from pigs in mainland China from 2000 to 2018: A systematic review and meta-analysis

Du, Z. and Wang, M. and Cui, G. and Zu, X. and Zhao, Z. and Xue, Y.

PLoS One (2020) 15: e0228388

DOI: 10.1371/journal.pone.0228388

Abstract

BACKGROUND: Amphenicols have been widely used in the pig industry in China, leading to varying degrees of drug resistance. METHODS: The systematic review was performed according to PRISMA (Preferred Reported Items for Systematic Reviews and Meta-Analysis) recommendations on studies investigating the prevalence of amphenicol-resistant Escherichia coli (E. coli) isolated from pig in mainland China from 2000 to 2018, a random-effects model was selected, then followed by meta-analysis. RESULTS: A total of 103 articles were included in the study. The results of the meta-analysis revealed that the pooled summarized prevalence of resistance to chloramphenicol (CAP) was 72.31% (95% confidence interval (95% CI) = 67.12%-77.23%) and to florfenicol (FF) was 58.64% (95% CI = 52.48%-64.67%). During the past 18 years, the resistance rate to CAP remained high initially but then declined rapidly after 2012, whereas the resistance rate to FF plateaued (54.13%-59.60%) from 2000-2018. In different parts of China, the rate of resistance to amphenicols among E. coli isolates was fairly consistent, with the exception of the north and northwest regions. CONCLUSIONS: In 2002, the veterinary use of CAP was prohibited and its resistance levels in E. coli isolated from pigs was initially maintained at a high level but then showed an obvious downward trend in recent years. Resistance to commonly used FF remained at a high but stable level.

Citation

Du, Z., Wang, M., Cui, G., Zu, X., Zhao, Z., & Xue, Y. (2020). The prevalence of amphenicol resistance in Escherichia coli isolated from pigs in mainland China from 2000 to 2018: A systematic review and meta-analysis. PLoS One, 15(2), e0228388. https://doi.org/10.1371/journal.pone.0228388 Animals, Swine, China/epidemiology, Anti-Bacterial Agents/pharmacology, *Drug Resistance, Bacterial, Chloramphenicol/*pharmacology, Escherichia coli Infections/drug therapy/epidemiology/microbiology/*veterinary, Escherichia coli/drug effects/*isolation & purification, Swine Diseases/drug therapy/*epidemiology/microbiology

Keywords

• Animals
• Swine
• China/epidemiology
• Anti-Bacterial Agents/pharmacology
• *Drug Resistance
• Bacterial
• Chloramphenicol/*pharmacology
• Escherichia coli Infections/drug therapy/epidemiology/microbiology/*veterinary
• Escherichia coli/drug effects/*isolation & purification
• Swine Diseases/drug therapy/*epidemiology/microbiology