VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Journal of Dairy Science (2008) 91: 1347–1360
A meta-analysis of the impact of monensin on production outcomes in dairy cattle was conducted using the 36 papers and 77 trials that contained eligible data. Statistical analyses were conducted in STATA and included a consideration of fixed or random effects models, assessment of publication bias, and impact of influential studies. Meta-regression was used to investigate sources of heterogeneity of response. There were 71 trials containing data from 255 trial sites and 9,677 cows examining milk production and composition. Monensin use in lactating dairy cattle significantly decreased dry matter intake by 0.3 kg, but increased milk yield by 0.7 kg and improved milk production efficiency by 2.5%. Monensin decreased milk fat percentage 0.13%, but had no effect on milk fat yield; however, there was significant heterogeneity between studies for both of these responses. Milk protein percentage was decreased 0.03%, but protein yield was increased 0.016 kg/d with treatment. Monensin had no effect on milk lactose percentage. Monensin increased body condition score by 0.03 and similarly improved body weight change (0.06 kg/d). Analysis of milk fatty acid profile data indicated that monensin was associated with a reduction of short-chain fatty acids (from 1 to 12% reduction) and stearic acid (-7.8%). The impact of monensin on linoleic and linolenic acids was variable, but monensin significantly increased conjugated linoleic acid (22%). Meta-regression of the effect of monensin on milk component percentages and yields indicated an influence of delivery method, stage of lactation, dose, and diet. Increasing concentrations of C18:1 in the diet enhanced the effect of monensin on decreasing milk fat yield, whereas increasing the rumen peptide balance increased the effect of monensin on milk protein yield. These findings indicate a benefit of monensin for improving milk production efficiency while maintaining body condition. The effect of monensin on milk fat percentage and yield was influenced by diet.
Duffield, T. F., Rabiee, A. R., & Lean, I. J. (2008). A meta-analysis of the impact of monensin in lactating dairy cattle. Part 2. Production effects. Journal of Dairy Science, 91(4), 1347–1360. https://doi.org/10.3168/jds.2007-0608 Animals, Female, Body Weight/drug effects, Diet/veterinary, Eating/drug effects, Cattle, Lactation/drug effects, Animal Nutritional Physiological Phenomena, Cattle/metabolism, Monensin/pharmacology, Dairying, Milk Proteins/analysis/drug effects, Body Constitution/drug effects, Fats/analysis, Ionophores/pharmacology, Milk/chemistry/drug effects