The function of nutraceuticals in the intestinal modulation of animals with non-alcoholic steatohepatitis: a systematic review

Fonseca, P. G. da and Ghetti, F. de F. and Figueiredo, S. M. de and Guimaraes, N. S.

Revista de Ciencias Medicas (2021) 30:

DOI: 10.24220/2318-0897v30e2021a4824

Abstract

Recent studies have observed the role of intestinal microbiota in the pathogenesis of non-alcoholic steatosis and described the relationship between alterations in the microbiota (dysbiosis) and inadequate dietary practices and obesity. Through a systematic synthesis, this review aims to establish which nutraceuticals can be used in the intestinal modulation of animal models with Non-Alcoholic Steatohepatitis. Based on Medical Subject Headings and Descritores em Ciencias da Saude descriptors, searches were performed on the PubMed, Web of Science, and Lilacs databases using the keywords: "Microbiota"; "Gastrointestinal Microbiome"; "Dysbiosis"; "Bacterial Translocation"; on-alcoholic fatty liver disease"; "Nonalcoholic Steatohepatitis", "Nutraceuticals"; and "Dietetic Supplements". After the methodological screening, seven studies were included. A total of 246 male Sprague Dawley rats with a mean age of four to eight weeks were evaluated. More than half of the studies (57.1%) used probiotics as nutraceuticals, 28.7% used tomato products, and 14.3% used symbiotics. The results suggest the positive effects of probiotics, tomato products, and symbiotics in the composition and functions of microorganisms resident in the intestines of animals with NASH, according to different mechanisms. Modulation of intestinal microbiota may contribute to minimizing the development and progression of "Nonalcoholic Steatohepatitis".

Citation

Fonseca, P. G. da, Ghetti, F. de F., Figueiredo, S. M. de, & Guimaraes, N. S. (2021). The function of nutraceuticals in the intestinal modulation of animals with non-alcoholic steatohepatitis: a systematic review. Revista De Ciencias Medicas, 30(1). https://doi.org/10.24220/2318-0897v30e2021a4824 Animals, Dietary Supplements, animal models, systematic reviews, intestines, laboratory animals, microorganisms, steatosis, pathogenesis, probiotics, microbial flora, functional foods, tomatoes, intestinal microorganisms, Animal Shells, Alcoholics, Fatty Liver

Keywords

• Animals
• Dietary Supplements
• animal models
• systematic reviews
• intestines
• laboratory animals
• microorganisms
• steatosis
• pathogenesis
• probiotics
• microbial flora
• functional foods
• tomatoes
• intestinal microorganisms
• Animal Shells
• Alcoholics
• Fatty Liver