A systematic review and meta-analysis of Hymenolepis nana in human and rodent hosts in Iran: a remaining public health concern

Goudarzi, F. and Mohtasebi, S. and Teimouri, A. and Yimam, Y. and Heydarian, P. and Sangani, G. S. and Afshar, M. J. A.

Comparative Immunology, Microbiology & Infectious Diseases (2021) 74: 74

DOI: 10.1016/j.cimid.2020.101580

Abstract

Hymenolepis nana, as a neglected zoonotic helminth, naturally occurs in both humans and rodents. Herein, a systematic review and meta-analysis was carried out to estimate pooled prevalence of H. nana infection among human and rodent hosts for the first time in Iran. PubMed, Web of Science, Scopus, and Embase databases (English articles) and SID and Magiran databases (Persian articles) were systematically searched for relevant studies published from inception till May 24, 2020. Chi^\textrm2 and I^\textrm2 index were used to assess the heterogeneity of the included studies. Publication bias was assessed using Egger’s intercept and visual inspection of the funnel plot. Pooled prevalence was estimated using random-effects model with 95% confidence interval (CI) and depicted as a forest plot. STATA software was used for analysis. The overall pooled prevalence estimate of H. nana in humans included 1.2% (95% CI=1.0-1.4%). Subgroup analysis revealed 2.2% (95% CI=1.8-2.6%) and 0.5% (95% CI=0.3 to 0.8%) of H. nana infection among school children and food handlers, respectively. In terms of rodent hosts, the overall pooled prevalence of H. nana infection included 13% (95% CI=9.3-16.6%). Subgroup analysis revealed the highest rate of the infection was in Rattus spp. (19.6%; 95% CI=10.6-28.6%), a genus with synanthropic behavior. It seems, despite the advancement in sanitation infrastructure and hygiene status, the H. nana infection compares to other helminthic diseases remains a challenging public health problem in Iran.

Citation

Goudarzi, F., Mohtasebi, S., Teimouri, A., Yimam, Y., Heydarian, P., Sangani, G. S., & Afshar, M. J. A. (2021). A systematic review and meta-analysis of Hymenolepis nana in human and rodent hosts in Iran: a remaining public health concern. Comparative Immunology, Microbiology & Infectious Diseases, 74, 74. https://doi.org/10.1016/j.cimid.2020.101580 Humans, meta-analysis, man, systematic reviews, data analysis, children, human diseases, public health, zoonoses, zoonotic infections, publications, helminthoses, helminths, infections, parasites, parasitoses, Hymenolepis nana, Iran, Rodentia, parasitic diseases, parasitic infestations, parasitosis, Protozoan, Helminth and Arthropod Parasites of Humans [VV220], parasitic worms, Public Health Pests, Vectors and Intermediate Hosts [VV230], rodents, Pathogens, Parasites and Infectious Diseases (Wild Animals) [YY700], Rattus, sanitation, food handlers, Hymenolepididae, Hymenolepis (Cestoda), school children, school kids, schoolchildren, synanthropy, Humanism, Humanities

Keywords

• Humans
• meta-analysis
• man
• systematic reviews
• data analysis
• children
• human diseases
• public health
• zoonoses
• zoonotic infections
• publications
• helminthoses
• helminths
• infections
• parasites
• parasitoses
• Hymenolepis nana
• Iran
• Rodentia
• parasitic diseases
• parasitic infestations
• parasitosis
• Protozoan
• Helminth and Arthropod Parasites of Humans [VV220]
• parasitic worms
• Public Health Pests
• Vectors and Intermediate Hosts [VV230]
• rodents
• Pathogens
• Parasites and Infectious Diseases (Wild Animals) [YY700]
• Rattus
• sanitation
• food handlers
• Hymenolepididae
• Hymenolepis (Cestoda)
• school children
• school kids
• schoolchildren
• synanthropy
• Humanism
• Humanities