Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis

Guo, C and Wang, WJ and Liao, YC and Zhao, C and Yin, Y and Yao, MN and Ding, Y and Wang, JW

Oxidative medicine and cellular longevity (2022) 2022: 9749461

DOI: 10.1155/2022/9749461

Abstract

Quercetin, a naturally occurring flavonoid, is mainly extracted from tea, onions, and apples. It has the underlying neuroprotective effect on experimental ischemic stroke. A systematic review and meta-analysis were used to assess quercetin’s efficacy and possible mechanisms in treating focal cerebral ischemia. Compared with the control group, twelve studies reported a remarkable function of quercetin in improving the neurological function score (NFS) (P \textless 0.05), and twelve studies reported a significant effect on reducing infarct volume (P \textless 0.05). Moreover, two and three studies showed that quercetin could alleviate blood-brain barrier (BBB) permeability and brain water content, respectively. The mechanisms of quercetin against focal cerebral ischemia are diverse, involving antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. On the whole, the present study suggested that quercetin can exert a protective effect on experimental ischemic stroke. Although the effect size may be overestimated because of the quality of studies and possible publication bias, these results indicated that quercetin might be a promising neuroprotective agent for human ischemic stroke. This study is registered with PROSPERO, number CRD 42021275656.

Citation

Guo, C., Wang, W. J., Liao, Y. C., Zhao, C., Yin, Y., Yao, M. N., Ding, Y., & Wang, J. W. (2022). Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis. Oxidative Medicine and Cellular Longevity, 2022, 9749461. https://doi.org/10.1155/2022/9749461 Animals, Disease Models, Animal, Male, Rats, Humans, Rats, Sprague-Dawley, Treatment Outcome, Rats, Wistar, Neuroprotective Agents/*therapeutic use, Permeability/drug effects, Plant Extracts/*therapeutic use, Phytotherapy/*methods, Ischemic Stroke/*drug therapy, Blood-Brain Barrier/drug effects/metabolism, Brain Ischemia, Cerebral Infarction/*drug therapy, Phytochemicals/*therapeutic use, Quercetin/*therapeutic use

Keywords

• Animals
• Disease Models
• Animal
• Male
• Rats
• Humans
• Rats
• Sprague-Dawley
• Treatment Outcome
• Rats
• Wistar
• Neuroprotective Agents/*therapeutic use
• Permeability/drug effects
• Plant Extracts/*therapeutic use
• Phytotherapy/*methods
• Ischemic Stroke/*drug therapy
• Blood-Brain Barrier/drug effects/metabolism
• Brain Ischemia
• Cerebral Infarction/*drug therapy
• Phytochemicals/*therapeutic use
• Quercetin/*therapeutic use