Animals as potential reservoirs for dengue transmission: a systematic review

Gwee, XiaoWei and St John, A. L. and Gray, G. C. and Pang, JunXiong

One Health (2021) 12:

DOI: 10.1016/j.onehlt.2021.100216

Abstract

Dengue is a rapidly spreading mosquito-borne flavivirus infection that is prevalent in tropical and sub-tropical regions. Humans are known to be the main reservoir host maintaining the epidemic cycles of dengue but it is unclear if dengue virus is also maintained in a similar enzootic cycle. The systematic review was conducted in accordance to Cochrane’s PRISMA recommendations. A search was done on PubMed, EMBASE, Scopus and Cochrane Library. Key data on animal dengue positivity was extracted and classified according to animal type and diagnostic modes. Of the 3818 articles identified, 56 articles were used in this review. A total of 16,333 animals were tested, 1817 of which were positive for dengue virus by RT-PCR or serology. Dengue positivity was detected in bats (10.1%), non-human primates (27.3%), birds (11%), bovid (4.1%), dogs (1.6%), horses (5.1%), pigs (34.1%), rodents (3.5%), marsupials (13%) and other small animals (7.3%). While majority of dengue positivity via serology suggests potential enzootic transmission, but regular dengue virus spillback cannot be excluded. With the exception of bats, acute infection among animals is limited. Further investigation on animals is critically required to better understand their role as potential reservoir in dengue transmission.

Citation

Gwee, X. W., St John, A. L., Gray, G. C., & Pang, J. X. (2021). Animals as potential reservoirs for dengue transmission: a systematic review. One Health, 12(104). https://doi.org/10.1016/j.onehlt.2021.100216 Animals, Primates, dogs, hogs, pigs, swine, Equus, horses, man, guidelines, recommendations, disease prevalence, birds, disease transmission, hosts, reservoir hosts, viral diseases, dengue, PCR, Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210], animal reservoirs, Public Health Pests, Vectors and Intermediate Hosts [VV230], viral infections, vector-borne diseases, Dengue virus, rodents, mosquito-borne diseases, Pathogens, Parasites and Infectious Diseases (Wild Animals) [YY700], polymerase chain reaction, real time PCR, epidemics, acute infections, Chiroptera, marsupials, severe infections, Animal Shells

Keywords

• Animals
• Primates
• dogs
• hogs
• pigs
• swine
• Equus
• horses
• man
• guidelines
• recommendations
• disease prevalence
• birds
• disease transmission
• hosts
• reservoir hosts
• viral diseases
• dengue
• PCR
• Prion
• Viral
• Bacterial and Fungal Pathogens of Humans [VV210]
• animal reservoirs
• Public Health Pests
• Vectors and Intermediate Hosts [VV230]
• viral infections
• vector-borne diseases
• Dengue virus
• rodents
• mosquito-borne diseases
• Pathogens
• Parasites and Infectious Diseases (Wild Animals) [YY700]
• polymerase chain reaction
• real time PCR
• epidemics
• acute infections
• Chiroptera
• marsupials
• severe infections
• Animal Shells