In vitro and in vivo antitumor activity of vitamin D3 in malignant gliomas: a systematic review

Hajimohammadebrahim-Ketabforoush, M. and Shariatpanahi, Z. V. and Shahmohammadi, M.

International Journal of Cancer Management (2020) 13:

DOI: 10.5812/ijcm.94542

Abstract

Context: The most common type of brain tumors are gliomas, among which glioblastoma multiforme is the most life-threatening. In spite of the existing treatments, malignant gliomas often do not respond to treatment. Objectives: The aim of this study was to investigate the antitumor activity of vitamin D3 in malignant gliomas through the study of in vitro and in vivo articles. Data Sources: The electronic databases, including PubMed, ScienceDirect, Web of Science, Google Scholar, and the Cochrane Central Register of Clinical Trials (last updated April 12th, 2019) were searched, using medical subject headings (MeSH) keywords "vitamin D AND brain malignancy". Data Extraction: There was no limitation on the date and language of the articles. A review of all the found articles at the level of titles and abstracts was made to find eligible articles. Our work is in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The quality of the articles was judged in accordance with the GRADE tool for in vitro studies and CIRCLEs RoB tool for in vivo studies.

Citation

Hajimohammadebrahim-Ketabforoush, M., Shariatpanahi, Z. V., & Shahmohammadi, M. (2020). In vitro and in vivo antitumor activity of vitamin D3 in malignant gliomas: a systematic review. International Journal of Cancer Management, 13(2). https://doi.org/10.5812/ijcm.94542 glioma, meta-analysis, animal models, man, patients, systematic reviews, data analysis, guidelines, health, recommendations, research, studies, vitamins, in vitro, human diseases, derivatives, neoplasms, clinical trials, Nutrition related Disorders and Therapeutic Nutrition [VV130], Non-communicable Human Diseases and Injuries [VV600], Animal Models of Human Diseases [VV400], cancers, brain, cerebrum, cell culture, Animal Models of Human Nutrition [VV140], vitamin D, analogs, analogues, cell elongation, cell growth, cholecalciferol, vitamin D3

Keywords

• glioma
• meta-analysis
• animal models
• man
• patients
• systematic reviews
• data analysis
• guidelines
• health
• recommendations
• research
• studies
• vitamins
• in vitro
• human diseases
• derivatives
• neoplasms
• clinical trials
• Nutrition related Disorders and Therapeutic Nutrition [VV130]
• Non-communicable Human Diseases and Injuries [VV600]
• Animal Models of Human Diseases [VV400]
• cancers
• brain
• cerebrum
• cell culture
• Animal Models of Human Nutrition [VV140]
• vitamin D
• analogs
• analogues
• cell elongation
• cell growth
• cholecalciferol
• vitamin D3