Outcomes of treatments for keratomalacia in dogs and cats: a systematic review of the published literature including non-randomised controlled and non-controlled studies

Hartley, C.

Journal of Small Animal Practice (2021) 62: 840–849

DOI: 10.1111/jsap.13326

Abstract

Objectives: The aim of this review was to interrogate the evidence base for treatment of keratomalacia in dogs and cats, through examination of the applicable literature. Materials and Methods: Studies were screened for evidence to answer the following question Which of the treatment options for keratomalacia in dogs and cats offers the best chance of globe survival, the fastest time to resolution with globe survival, and the best visual outcome. The search utilised the PubMed (http://www.pubmed.gov/) and ISI Web of Science (http://wok.mimas.ac.uk/) databases. Databases were searched using the following terms: (keratomalacia OR corneal melt OR corneal malacia) AND (dog OR canine OR canid OR cat OR feline OR felid) AND (treatment OR outcome OR morbidity OR complications). Studies were assessed by one author (CH) and excluded if they related to less than three keratomalacia cases, experimental treatments, in vitro studies, or did not provide information regarding outcome. Studies were classified to a level of evidence according to the system described by the Oxford Centre for EvidenceBased Medicine.

Citation

Hartley, C. (2021). Outcomes of treatments for keratomalacia in dogs and cats: a systematic review of the published literature including non-randomised controlled and non-controlled studies. Journal of Small Animal Practice, 62(10), 840–849. https://doi.org/10.1111/jsap.13326 prognosis, dogs, reviews, Diagnosis of Animal Diseases [LL886], meta-analysis, eyes, systematic reviews, therapeutics, therapy, Mathematics and Statistics [ZZ100], Animal Surgery and Non-drug Therapy [LL884], Non-communicable Diseases and Injuries of Animals [LL860], cats, Pets and Companion Animals [LL070], in vitro, complications, clinical aspects, diagnosis, survival, Veterinary Pharmacology and Anaesthesiology [LL882], clinical picture, eye diseases, cornea, eye cornea, morbidity, keratomalacia

Keywords

• prognosis
• dogs
• reviews
• Diagnosis of Animal Diseases [LL886]
• meta-analysis
• eyes
• systematic reviews
• therapeutics
• therapy
• Mathematics and Statistics [ZZ100]
• Animal Surgery and Non-drug Therapy [LL884]
• Non-communicable Diseases and Injuries of Animals [LL860]
• cats
• Pets and Companion Animals [LL070]
• in vitro
• complications
• clinical aspects
• diagnosis
• survival
• Veterinary Pharmacology and Anaesthesiology [LL882]
• clinical picture
• eye diseases
• cornea
• eye cornea
• morbidity
• keratomalacia