VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Environ Pollut (2020) 256: 113306
DOI: 10.1016/j.envpol.2019.113306
BACKGROUND: Exposure to particulate matters (PM) is recognized as an important risk factor for cardiovascular disease. A change in cardiac autonomic function is one postulated mechanism leading to PM related cardiovascular events. This study therefore evaluated the associations of short-term exposure to PM and heart rate variability (HRV) parameters, which can reflect the cardiac autonomic function. METHODS: Four electronic databases were searched for controlled studies of rodents published prior to December 2018. A systematic review and meta-analysis was conducted. Effect sizes were calculated for five main HRV parameters, including standard deviation of normal-to-normal intervals (SDNN), square root of mean squared differences between successive normal-to-normal intervals (rMSSD), low frequency (LF), high frequency (HF), and the ratio of LF and HF (LF/HF). RESULTS: The review included 23 studies with 401 animals. Short-term exposure to PM by instillation yielded statistically significant effects on SDNN (Standardized Mean Difference [SMD] = -1.11, 95% Confidence Intervals [CI] = -2.22 to -0.01, P = 0.05), LF (SMD = -1.19, 95% CI = -1.99 to -0.40, P = 0.003) and LF/HF (SMD = -1.05, 95% CI = -2.03 to -0.07, P = 0.04). Short-term exposure to PM by inhalation only yielded statistically significant effect on LF/HF (SMD = -0.83, 95% CI = -1.39 to -0.27, P = 0.004). There was no evidence that animal model and exposure frequency influenced the relationship of PM and HRV. CONCLUSIONS: Short-term exposure to PM can decrease HRV of rodents, affecting cardiac autonomic function. Exposure methods can influence the relationships of PM and HRV parameters. Further studies should focus on the effects of long-term PM exposure, on human beings, and potential influential factors of PM-HRV associations.
Huang, F., Wang, P., Pan, X., Wang, Y., & Ren, S. (2020). Effects of short-term exposure to particulate matters on heart rate variability: A systematic review and meta-analysis based on controlled animal studies. Environ Pollut, 256, 113306. https://doi.org/10.1016/j.envpol.2019.113306 Animals, Male, Rats, Female, Humans, Mice, Risk Factors, Meta-analysis, Systematic review, Databases, Factual, Heart rate variability, Air Pollutants/*toxicity, Animal study, Heart Rate/*drug effects, Inhalation Exposure/*adverse effects/analysis, Particulate matter, Particulate Matter/*toxicity