VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Epidemiol Infect (2020) 148: e239
DOI: 10.1017/s0950268820002290
Severe fever with thrombocytopenia syndrome (SFTS) is a disease with a high case-fatality rate that is caused by infection with the SFTS virus (SFTSV). Five electronic databases were systematically searched to identify relevant articles published from 1 January 2011 to 1 December 2019. The pooled rates with 95% confidence interval (CI) were calculated by a fixed-effect or random-effect model analysis. The results showed that 92 articles were included in this meta-analysis. For the confirmed SFTS cases, the case-fatality rate was 0.15 (95% CI 0.11, 0.18). Two hundred and ninety-six of 1384 SFTS patients indicated that they had been bitten by ticks and the biting rate was 0.21 (95% CI 0.16, 0.26). The overall pooled seroprevalence of SFTSV antibodies among the healthy population was 0.04 (95% CI 0.03, 0.05). For the overall seroprevalence of SFTSV in animals, the seroprevalence of SFTSV was 0.25 (95% CI 0.20, 0.29). The infection rate of SFTSV in ticks was 0.08 (95% CI 0.05, 0.11). In conclusion, ticks can serve as transmitting vectors of SFTSVs and reservoir hosts. Animals can be infected by tick bites, and as a reservoir host, SFTSV circulates continuously between animals and ticks in nature. Humans are infected by tick bites and direct contact with patient secretions.
Huang, X. Y., He, Z. Q., Wang, B. H., Hu, K., Li, Y., & Guo, W. S. (2020). Severe fever with thrombocytopenia syndrome virus: a systematic review and meta-analysis of transmission mode. Epidemiol Infect, 148, e239. https://doi.org/10.1017/s0950268820002290 Animals, Humans, *Meta-analysis, Disease Notification, *severe fever with thrombocytopenia syndrome virus, *ticks, *transmission mode, Phlebovirus/*physiology, Severe Fever with Thrombocytopenia Syndrome/transmission/*virology, Tick Bites, Ticks/virology