Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution

Jarosz, A. C. and Badawi, A.

Inflammation Research (2019) 68: 7–17

DOI: 10.1007/s00011-018-1180-5

Abstract

Background: Lyme disease or Lyme borreliosis (LB) is the commonest vector-borne disease in the North America. It is an inflammatory disease caused by the bacterium Borrelia burgdorferi. The role of the inflammatory processes mediated by prostaglandins (PGs), thromboxanes and leukotrienes (LTs) in LB severity and symptoms resolution is yet to be elucidated. Objectives: We aim to systematically review and evaluate the role of PGs and related lipid mediators in the induction and resolution of inflammation in LB.

Citation

Jarosz, A. C., & Badawi, A. (2019). Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution. Inflammation Research, 68(1), 7–17. https://doi.org/10.1007/s00011-018-1180-5 biomarkers, inflammation, animal models, man, systematic reviews, lipids, lipins, in vitro, bacterium, human diseases, biochemical markers, metabolites, bacterial diseases, drug therapy, antibacterial agents, experimental infections, antibiotics, bacterial infections, bacterioses, chemotherapy, Animal Models of Human Diseases [VV400], Pesticides and Drugs, Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210], Control [HH405], Borrelia burgdorferi, symptoms, non-steroidal antiinflammatory agents, NSAIDS, Lyme disease, arthritis, bacterial meningitis, cell cultures, joints (animal), lyme borreliosis, phosphatidase, phospholipase A2, prostaglandin synthase, prostaglandins

Keywords

• biomarkers
• inflammation
• animal models
• man
• systematic reviews
• lipids
• lipins
• in vitro
• bacterium
• human diseases
• biochemical markers
• metabolites
• bacterial diseases
• drug therapy
• antibacterial agents
• experimental infections
• antibiotics
• bacterial infections
• bacterioses
• chemotherapy
• Animal Models of Human Diseases [VV400]
• Pesticides and Drugs
• Prion
• Viral
• Bacterial and Fungal Pathogens of Humans [VV210]
• Control [HH405]
• Borrelia burgdorferi
• symptoms
• non-steroidal antiinflammatory agents
• NSAIDS
• Lyme disease
• arthritis
• bacterial meningitis
• cell cultures
• joints (animal)
• lyme borreliosis
• phosphatidase
• phospholipase A2
• prostaglandin synthase
• prostaglandins