Intake of Fish and Marine n-3 Polyunsaturated Fatty Acids and Risk of Cardiovascular Disease Mortality: A Meta-Analysis of Prospective Cohort Studies

Jiang, L. and Wang, J. and Xiong, K. and Xu, L. and Zhang, B. and Ma, A.

Nutrients (2021) 13:

DOI: 10.3390/nu13072342

Abstract

Previous epidemiological studies have investigated the association of fish and marine n-3 polyunsaturated fatty acids (n-3 PUFA) consumption with cardiovascular disease (CVD) mortality risk. However, the results were inconsistent. The purpose of this meta-analysis is to quantitatively evaluate the association between marine n-3 PUFA, fish and CVD mortality risk with prospective cohort studies. A systematic search was performed on PubMed, Web of Science, Embase and MEDLINE databases from the establishment of the database to May 2021. A total of 25 cohort studies were included with 2,027,512 participants and 103,734 CVD deaths. The results indicated that the fish consumption was inversely associated with the CVD mortality risk [relevant risk (RR) = 0.91; 95% confidence intervals (CI) 0.85-0.98]. The higher marine n-3 PUFA intake was associated with the reduced risk of CVD mortality (RR = 0.87; 95% CI: 0.85-0.89). Dose-response analysis suggested that the risk of CVD mortality was decreased by 4% with an increase of 20 g of fish intake (RR = 0.96; 95% CI: 0.94-0.99) or 80 milligrams of marine n-3 PUFA intake (RR = 0.96; 95% CI: 0.94-0.98) per day. The current work provides evidence that the intake of fish and marine n-3 PUFA are inversely associated with the risk of CVD mortality.

Citation

Jiang, L., Wang, J., Xiong, K., Xu, L., Zhang, B., & Ma, A. (2021). Intake of Fish and Marine n-3 Polyunsaturated Fatty Acids and Risk of Cardiovascular Disease Mortality: A Meta-Analysis of Prospective Cohort Studies. Nutrients, 13(7). https://doi.org/10.3390/nu13072342 Animals, Male, Adult, Aged, Aged, 80 and over, Female, Humans, Middle Aged, Adolescent, Young Adult, Prospective Studies, meta-analysis, fish, Fishes, Heart Disease Risk Factors, *Seafood, prospective cohort studies, Fatty Acids, Omega-3/*administration & dosage, Eating/*physiology, cardiovascular disease mortality, Cardiovascular Diseases/metabolism/*mortality, Diet/methods/*mortality, n-3 polyunsaturated fatty acid

Keywords

• Animals
• Male
• Adult
• Aged
• Aged
• 80 and over
• Female
• Humans
• Middle Aged
• Adolescent
• Young Adult
• Prospective Studies
• meta-analysis
• fish
• Fishes
• Heart Disease Risk Factors
• *Seafood
• prospective cohort studies
• Fatty Acids
• Omega-3/*administration & dosage
• Eating/*physiology
• cardiovascular disease mortality
• Cardiovascular Diseases/metabolism/*mortality
• Diet/methods/*mortality
• n-3 polyunsaturated fatty acid