VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
BioFactors (2020) 46: 21–37
DOI: 10.1002/biof.1569
Diabetes mellitus and pre-diabetes are prevalent endocrine disorders associated with substantial morbidity and premature mortality. Vitamin K is known to have several beneficial effects on complications of diabetes and pre-diabetes. However, systematic consolidation of evidence is required to quantify these effects in order to inform clinical practice and research. A systematic search in PubMed, Scopus, Embase, ProQuest, and Google Scholar databases was undertaken from database inception up to October 2018 to evaluate functional roles of different forms of vitamin K on diabetes and pre-diabetes. From 3, 734 identified records, nine articles met the inclusion criteria and were evaluated. Vitamin K supplementation was found to be associated with significant reductions in blood glucose (six studies), increased fasting serum insulin (four studies), reduced hemoglobin A1c (three studies), reduced homeostatic model assessment-insulin resistance index (HOMA-IR) (two studies), and increased ss-cell function (two studies) in diabetic animal studies. Following 2-hour oral glucose tolerance test, vitamin K supplementation was observed to be effective in reducing blood glucose and insulin levels in the pre-diabetic population. However, no evidence of effect was observed for fasting blood sugar, insulin, HOMA-IR, and homeostatic model assessment-beta-cell function index (two studies). A statistically significant effect was also noted with vitamin K in improving dyslipidemia (three studies) as well as oxidative stress and inflammatory markers (five studies) in diabetic animals. In conclusion, clinical trials and animal studies confirm that vitamin K supplementation may improve both clinical features and complications of diabetes and pre-diabetes. However, quantification of clinical efficacy in the pre-diabetic population and among individuals with comorbidities requires further investigation.
Karamzad, N., Maleki, V., Carson-chahhoud, K., Azizi, S., Sahebkar, A., & Gargari, B. P. (2020). A systematic review on the mechanisms of vitamin K effects on the complications of diabetes and pre-diabetes. BioFactors, 46(1), 21–37. https://doi.org/10.1002/biof.1569 animal models, man, systematic reviews, literature reviews, human diseases, complications, laboratory animals, antiinflammatory properties, antioxidant properties, insulin, disease models, insulin resistance, blood sugar, diabetes mellitus, type 2 diabetes, Nutrition related Disorders and Therapeutic Nutrition [VV130], Non-communicable Human Diseases and Injuries [VV600], Animal Models of Human Diseases [VV400], anti-inflammatory properties, anti-oxidant properties, Animal Models of Human Nutrition [VV140], blood glucose, glucose in blood, anti-diabetic properties, anti-hyperglycaemic properties, antidiabetic properties, antihyperglycaemic properties, haemoglobin A1, hemoglobin A1, hyperlipaemia, hyperlipemia, hypoglycaemic properties, hypoglycemic properties, hypolipaemic properties, hypolipemic properties, hypolipidaemic properties, hypolipidemic properties, radical scavenging properties, vitamin K