A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis

Karimi, A. and Naeini, F. and Asghari Azar, V. and Hasanzadeh, M. and Ostadrahimi, A. and Niazkar, H. R. and Mobasseri, M. and Tutunchi, H.

Phytomedicine (2021) 86: 86

DOI: 10.1016/j.phymed.2021.153567

Abstract

Background: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological actions including free radical scavenging and antioxidant activities . Quercetin, one of the most extensively distributed flavonoids in the vegetables and fruits, presents various biological activities including modulation of oxidative stress, anti-infectious, anti-inflammatory, and neuroprotective activities.

Citation

Karimi, A., Naeini, F., Asghari Azar, V., Hasanzadeh, M., Ostadrahimi, A., Niazkar, H. R., Mobasseri, M., & Tutunchi, H. (2021). A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis. Phytomedicine, 86, 86. https://doi.org/10.1016/j.phymed.2021.153567 oxidative stress, inflammation, meta-analysis, systematic reviews, plants, medicinal plants, plant extracts, antiinflammatory properties, flavonoids, sepsis, immune response, immunity reactions, immunological reactions, Animal and in vitro Models for Pharmaceuticals [VV450], Animal Models of Human Diseases [VV400], Pesticides and Drugs, quercetin, Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210], drug plants, Horticultural Crops [FF003], medicinal herbs, officinal plants, Control [HH405], Non-food/Non-feed Plant Products [SS200], anti-inflammatory properties, vegetable crops, vegetables, fruits, messenger RNA, mRNA, toll-like receptors

Keywords

• oxidative stress
• inflammation
• meta-analysis
• systematic reviews
• plants
• medicinal plants
• plant extracts
• antiinflammatory properties
• flavonoids
• sepsis
• immune response
• immunity reactions
• immunological reactions
• Animal and in vitro Models for Pharmaceuticals [VV450]
• Animal Models of Human Diseases [VV400]
• Pesticides and Drugs
• quercetin
• Prion
• Viral
• Bacterial and Fungal Pathogens of Humans [VV210]
• drug plants
• Horticultural Crops [FF003]
• medicinal herbs
• officinal plants
• Control [HH405]
• Non-food/Non-feed Plant Products [SS200]
• anti-inflammatory properties
• vegetable crops
• vegetables
• fruits
• messenger RNA
• mRNA
• toll-like receptors