Antibiotic resistance genes in the aquaculture sector: global reports and research gaps

Kemp, J. O. G. and Taylor, J. J. and Kelly, L. A. and Larocque, R. and Heriazon, A. and Tiessen, K. H. D. and Cookeauthors, S. J.

Environmental Reviews (2020) 29: 300–314

DOI: 10.1139/er-2020-0087

Abstract

Aquaculture has been one of the fastest-growing food production systems over the last decade and increased intensification of production has created conditions that favour disease outbreaks. Antibiotics are commonly applied in the food animal sector to fight against bacterial infections; however, their inappropriate use contributes to the emergence of antibiotic-resistant bacteria. Investment in research and capacity-strengthening, in parallel with enforcing existing regulations around antimicrobial use, are potentially powerful tools in tackling the threat of antimicrobial resistance (AMR) emanating from animal producing systems such as aquaculture. However, directing investment effectively is challenging due to the limited data available that hinder the identification of risk areas for current and future AMR emergence. Here, we aim to partially fill this gap by analyzing the current peer-reviewed literature reporting antibiotic resistance genes (ARGs) in aquaculture food production systems and combining the data in a systematic map. Systematic searches of three bibliographic databases, a search engine, and 120 reviews returned 10 699 articles that were screened at title and abstract and then by full text (n = 1100). Two hundred and eighteen articles, spanning 39 countries and six continents, met all inclusion criteria and were coded to retrieve bibliographic, methodology, and study outcome data. ARG detections were associated with 44 families of fish and crustaceans and 75 genera of bacteria, with most studies employing primer-based methods to detect ARGs. A narrative synthesis explores implications for future research and policy as well as limitations of the systematic mapping methodology.

Citation

Kemp, J. O. G., Taylor, J. J., Kelly, L. A., Larocque, R., Heriazon, A., Tiessen, K. H. D., & Cookeauthors, S. J. (2020). Antibiotic resistance genes in the aquaculture sector: global reports and research gaps. Environmental Reviews, 29(2), 300–314. https://doi.org/10.1139/er-2020-0087 reviews, systematic reviews, Aquaculture (Animals) [MM120], aquatic animals, aquatic organisms, aquatic species, fishes, bacterium, drug resistance, Pesticide and Drug Resistance [HH410], Laws and Regulations [DD500], Information and Documentation [CC300], policy, genes, bacterial diseases, databases, aquaculture, data banks, Crustacea, antibiotics, bacterial infections, bacterioses, Pesticides and Drugs, Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821], antiinfective agents, antimicrobials, Control [HH405], antibiotic resistance, infection control, intensive production

Keywords

• reviews
• systematic reviews
• Aquaculture (Animals) [MM120]
• aquatic animals
• aquatic organisms
• aquatic species
• fishes
• bacterium
• drug resistance
• Pesticide and Drug Resistance [HH410]
• Laws and Regulations [DD500]
• Information and Documentation [CC300]
• policy
• genes
• bacterial diseases
• databases
• aquaculture
• data banks
• Crustacea
• antibiotics
• bacterial infections
• bacterioses
• Pesticides and Drugs
• Prion
• Viral
• Bacterial and Fungal Pathogens of Animals [LL821]
• antiinfective agents
• antimicrobials
• Control [HH405]
• antibiotic resistance
• infection control
• intensive production