Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: a systematic review

Khademi, F. and Derakhshan, M. and Yousefi-Avarvand, A. and Tafaghodi, M.

Iranian Journal of Basic Medical Sciences (2018) 21: 116–123

DOI: 10.22038/IJBMS.2017.22059.5648

Abstract

Objective(s): Production of effective tuberculosis (TB) vaccine is necessity. However, the development of new subunit vaccines is faced with concerns about their weak immunogenicity. To overcome such problems, polymers-based vaccine delivery systems have been proposed to be used via various routes. The purpose of this study was to determine the potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against TB. Materials and Methods: PubMed, Scopus, Science-Direct, and the ISI web of knowledge databases were searched for related keywords. A total of 420 articles, written up to June 25, 2016, were collected on the potential of polymeric particles as TB vaccine delivery systems after parenteral and non-parenteral immunization. Thirty-one relevant articles were selected by applying inclusion and exclusion criteria.

Citation

Khademi, F., Derakhshan, M., Yousefi-Avarvand, A., & Tafaghodi, M. (2018). Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: a systematic review. Iranian Journal of Basic Medical Sciences, 21(2), 116–123. https://doi.org/10.22038/IJBMS.2017.22059.5648 disease prevention, Host Resistance and Immunity [HH600], vaccination, vaccines, animal models, tuberculosis, immunization, immune response, experimental infections, adjuvants, administration routes, antigens, drug delivery systems, lung diseases, respiratory diseases, Mycobacterium tuberculosis, immunity reactions, immunological reactions, immune sensitization, Animal and in vitro Models for Pharmaceuticals [VV450], Animal Models of Human Diseases [VV400], lungs, Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210], antigenicity, immunogens, cell mediated immunity, cellular immunity, chitosan

Keywords

• disease prevention
• Host Resistance and Immunity [HH600]
• vaccination
• vaccines
• animal models
• tuberculosis
• immunization
• immune response
• experimental infections
• adjuvants
• administration routes
• antigens
• drug delivery systems
• lung diseases
• respiratory diseases
• Mycobacterium tuberculosis
• immunity reactions
• immunological reactions
• immune sensitization
• Animal and in vitro Models for Pharmaceuticals [VV450]
• Animal Models of Human Diseases [VV400]
• lungs
• Prion
• Viral
• Bacterial and Fungal Pathogens of Humans [VV210]
• antigenicity
• immunogens
• cell mediated immunity
• cellular immunity
• chitosan