Resveratrol: A "miracle" drug in neuropsychiatry or a cognitive enhancer for mice only? A systematic review and meta-analysis

Khorshidi, F. and Poljak, A. and Liu, Y. and Lo, J. W. and Crawford, J. D. and Sachdev, P. S.

Ageing Res Rev (2021) 65: 101199

DOI: 10.1016/j.arr.2020.101199

Abstract

BACKGROUND: Over the last decade resveratrol has been trialled for the prevention and treatment of cognitive decline; however, the results have shown a conflict between human studies compared with animal studies, especially on cognition, blood pressure, neuroimaging, and mood. METHODS: Human clinical trials and animal studies published prior to January 2020, were identified searching across major electronic databases. PRISMA guidelines were used for data extraction, which was independently performed by two authors. Pooled standard mean difference (SMD, random effect model) and odds ratios (ORs) were calculated. RESULTS: Most publications on animal models reported positive outcomes on cognition and brain function following exposure to resveratrol or grape seed extracts. By contrast, 11 meta-analyses of data from human placebo vs resveratrol, grape or wine treatment trials identified no statistically significant effect on a variety of measures, including cognitive and mood assessments, grey matter volume and blood pressure. CONCLUSIONS: Based on currently available data, the promising effects of resveratrol in animal models is not replicated in human clinical trials. The effects, if any, of resveratrol on human cognition are likely to be small. This work may be useful for the design and implementation of future pre-clinical and clinical studies using resveratrol in a neurological setting.

Citation

Khorshidi, F., Poljak, A., Liu, Y., Lo, J. W., Crawford, J. D., & Sachdev, P. S. (2021). Resveratrol: A "miracle" drug in neuropsychiatry or a cognitive enhancer for mice only? A systematic review and meta-analysis. Ageing Res Rev, 65, 101199. https://doi.org/10.1016/j.arr.2020.101199 Animals, Mice, *Meta-analysis, *Resveratrol, *Systematic review, *Pharmaceutical Preparations, *Dementia, *Cognition, *Alzheimer’s, *Cognitive Dysfunction/drug therapy, *Natural products, *Neuropsychiatry, *Nootropic Agents/pharmacology/therapeutic use, Resveratrol/pharmacology

Keywords

• Animals
• Mice
• *Meta-analysis
• *Resveratrol
• *Systematic review
• *Pharmaceutical Preparations
• *Dementia
• *Cognition
• *Alzheimer’s
• *Cognitive Dysfunction/drug therapy
• *Natural products
• *Neuropsychiatry
• *Nootropic Agents/pharmacology/therapeutic use
• Resveratrol/pharmacology