VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Int J Mol Sci (2019) 20:
DOI: 10.3390/ijms20020368
We have systematically assessed published cell studies and animal experimental reports on the efficacy of selected biophysical energies (BPEs) in the treatment of diabetic foot ulcers. These BPEs include electrical stimulation (ES), pulsed electromagnetic field (PEMF), extracorporeal shockwave (ECSW), photo energies and ultrasound (US). Databases searched included CINAHL, MEDLINE and PubMed from 1966 to 2018. Studies reviewed include animal and cell studies on treatment with BPEs compared with sham, control or other BPEs. Information regarding the objective measures of tissue healing and data was extracted. Eighty-two studies were eventually selected for the critical appraisal: five on PEMF, four each on ES and ECSW, sixty-six for photo energies, and three about US. Based on the percentage of original wound size affected by the BPEs, both PEMF and low-level laser therapy (LLL) demonstrated a significant clinical benefit compared to the control or sham treatment, whereas the effect of US did not reveal a significance. Our results indicate potential benefits of selected BPEs in diabetic wound management. However, due to the heterogeneity of the current clinical trials, comprehensive studies using well-designed trials are warranted to confirm the results.
Kwan, R. L., Lu, S., Choi, H. M., Kloth, L. C., & Cheing, G. L. (2019). Efficacy of Biophysical Energies on Healing of Diabetic Skin Wounds in Cell Studies and Animal Experimental Models: A Systematic Review. Int J Mol Sci, 20(2). https://doi.org/10.3390/ijms20020368 Animals, Disease Models, Animal, Humans, *Wound Healing, diabetes mellitus, systematic review, *Biophysical Phenomena, biophysical energies, cell, Diabetic Foot/*pathology/radiotherapy, Electric Stimulation, experimental models, Low-Level Light Therapy, skin wounds