VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Journal of Ethnopharmacology (2021) 265: 265
DOI: 10.1016/j.jep.2020.113301
Ethnopharmacological relevance: Xuebijing (XBJ) injection is a Chinese medicine containing extracts from Carthamus tinctorius L. (Carthami Flos, hong hua, Asteraceae), Paeonia lactiflora Pall. (Paeoniae radix rubra, chi shao, Ranunculaceae), Ligusticum chuanxiong Hort. (Chuanxiong Rhizoma, chuan xiong, Umbelliferae), Salvia miltiorrhiza Bge. (Salviae miltiorrhizae Radix Et Rhizoma, dan shen, Labiatae) and Angelica sinensis (Oliv.) Diels (Angelicae sinensis Radix, dang gui, Umbelliferae). It has been approved for the treatment of sepsis in China since 2004 and has been widely used as an add-on treatment for sepsis or septic shock with few side effects. Aim of the study: The aim of the present review was to analyse up-to-date information related to the treatment of sepsis with XBJ, including the bioactive constituents, clinical studies and potential mechanisms, and to discuss possible scientific gaps, to provide a reliable reference for future studies. Materials and methods: Scientific resources concentrating on treating sepsis with XBJ were searched through PubMed, the Chinese National Knowledge Infrastructure (CNKI) and WanFang databases from inception to November 2018. Dissertations were also searched, and eligible dissertations were selected. Studies related to the identification of constituents, bioactive components and their targets of action or pathways, clinical trials, and animal or cellular experiments that explored pharmacological mechanisms were manually selected. The quality of reporting and methodology of the included pharmacological experiments were assessed using the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE)’s risk of bias tool.
Li, C. Y., Wang, P., Li, M., Zheng, R., Chen, S. Q., Liu, S., Feng, Z. Q., Yao, Y. M., & Shang, H. C. (2021). The current evidence for the treatment of sepsis with Xuebijing injection: bioactive constituents, findings of clinical studies and potential mechanisms. Journal of Ethnopharmacology, 265, 265. https://doi.org/10.1016/j.jep.2020.113301 pharmacology, oxidative stress, China, reviews, animal models, man, plants, human diseases, medicinal plants, plant extracts, databases, antiinflammatory properties, randomized controlled trials, data banks, sepsis, clinical trials, Animal and in vitro Models for Pharmaceuticals [VV450], Animal Models of Human Diseases [VV400], Pesticides and Drugs, endothelium, People’s Republic of China, Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210], drug plants, Horticultural Crops [FF003], medicinal herbs, officinal plants, Control [HH405], Non-food/Non-feed Plant Products [SS200], Pharmacology [VV730], anti-inflammatory properties, body temperature, Angelica sinensis, anti-coagulant properties, anticoagulant properties, Carthamus tinctorius, leucocytes, leukocytes, Ligusticum chuanxiong, Paeonia lactiflora, safflower, Salvia miltiorrhiza, white blood cells