Is the rate of adverse reaction to rabies vaccine in China really as the public thinks?-based on a meta analysis

Li, W. and Liu, S. and Qian, S. and Zhu, J. and Selvaraj, J. N. and Zhang, X.

Hum Vaccin Immunother (2021) 17: 714–722

DOI: 10.1080/21645515.2020.1794218

Abstract

OBJECTIVE: To evaluate the rate of adverse reaction toward rabies vaccine in China from 2008 to 2019, explore its characteristics and to provide a scientific and objective basis for future policy decisions. METHODS: Literature on the rate of adverse reaction to rabies vaccine in China from 2008 to 2019 was retrieved and collected in CNKI, Wanfang, VIP databases, PubMed and Embase. A meta analysis was carried out then. RESULTS: Totally, 35 articles were included. The combined rate of adverse reaction to rabies vaccine was 5.6% (95% CI = 5.1% - 6.0%). Adverse reactions to rabies vaccine were 11.3% and 4.5% before and after 2011, 5.3% and 7.1% in the eastern and midwestern regions, 13.2%, 25.5% and 3.7% in the tertiary hospitals, secondary hospitals and primary medical institutions, respectively. And 13.3% were in the areas where the Changchun immortal vaccine was used. The combined rate of adverse reaction to rabies vaccine inoculated in Changsheng vaccine area was 5.1%. CONCLUSION: After 2011, the rate of adverse reaction to rabies vaccine in China has decreased dramatically. The rate of adverse reaction to rabies vaccine in the midwestern regions is higher than the counterpart in the eastern regions. The primary medical institutions are lower than the counterpart in the tertiary and secondary hospitals.

Citation

Li, W., Liu, S., Qian, S., Zhu, J., Selvaraj, J. N., & Zhang, X. (2021). Is the rate of adverse reaction to rabies vaccine in China really as the public thinks?-based on a meta analysis. Hum Vaccin Immunother, 17(3), 714–722. https://doi.org/10.1080/21645515.2020.1794218 meta analysis, adverse reaction, Rabies vaccine

Keywords

• meta analysis
• adverse reaction
• Rabies vaccine