VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Clin Endocrinol (Oxf) (2018) 89: 408–413
DOI: 10.1111/cen.13762
OBJECTIVE: Liver cirrhosis (LC) was associated with an increased risk of osteoporosis; however, the association between LC and fracture risk was inconclusive. Therefore, this systematic review and meta-analysis aims to explore the association between LC and fracture risk. DESIGN: To identify related literature, a systematic search of PubMed, EMBASE, Web of science and the Cochrane Library from 1965 to July 2017 without language limitation was performed. The random-effects model described by DerSimonian and Laird was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Eventually, 5 cohort and 3 case-control studies were identified, which included 321 035 subjects and 31 272 fracture cases. The pooled OR of the association between LC and any fracture risk, hip fracture, spine/trunk fracture and limb fracture was 1.94 (95% CI, 1.59-2.37), 2.11 (95% CI, 1.34-3.32), 2.00 (95% CI, 1.50-2.67) and 1.82 (95% CI, 1.65-2.01), respectively. CONCLUSION: In conclusion, this study indicates that cirrhotic patients have an increased risk of fracture. Preventive measures should be instituted as early as possible.
Liang, J., Meng, W. D., Yang, J. M., Li, S. L., Zhong, M. N., Hou, X. X., Wang, R., Long, Y. Y., Bao, L. X., & Bao, M. (2018). The association between liver cirrhosis and fracture risk: A systematic review and meta-analysis. Clin Endocrinol (Oxf), 89(4), 408–413. https://doi.org/10.1111/cen.13762 Animals, Humans, Risk Factors, Odds Ratio, Confidence Intervals, *meta-analysis, *cirrhosis, *fracture, *primary biliary cirrhosis, Fractures, Bone/*epidemiology, Hip Fractures/epidemiology, Liver Cirrhosis/*epidemiology