VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Pain Rep (2021) 6: e927
DOI: 10.1097/pr9.0000000000000927
Several animal and human studies revealed that joint and nerve mobilisations positively influence neuroimmune responses in neuromusculoskeletal conditions. However, no systematic review and meta-analysis has been performed. Therefore, this study aimed to synthesize the effects of joint and nerve mobilisation compared with sham or no intervention on neuroimmune responses in animals and humans with neuromusculoskeletal conditions. Four electronic databases were searched for controlled trials. Two reviewers independently selected studies, extracted data, assessed the risk of bias, and graded the certainty of the evidence. Where possible, meta-analyses using random effects models were used to pool the results. Preliminary evidence from 13 animal studies report neuroimmune responses after joint and nerve mobilisations. In neuropathic pain models, meta-analysis revealed decreased spinal cord levels of glial fibrillary acidic protein, dorsal root ganglion levels of interleukin-1β, number of dorsal root ganglion nonneuronal cells, and increased spinal cord interleukin-10 levels. The 5 included human studies showed mixed effects of spinal manipulation on salivary/serum cortisol levels in people with spinal pain, and no significant effects on serum β-endorphin or interleukin-1β levels in people with spinal pain. There is evidence that joint and nerve mobilisations positively influence various neuroimmune responses. However, as most findings are based on single studies, the certainty of the evidence is low to very low. Further studies are needed.
Lutke Schipholt, I. J., Coppieters, M. W., Meijer, O. G., Tompra, N., de Vries, R. B. M., & Scholten-Peeters, G. G. M. (2021). Effects of joint and nerve mobilisation on neuroimmune responses in animals and humans with neuromusculoskeletal conditions: a systematic review and meta-analysis. Pain Rep, 6(2), e927. https://doi.org/10.1097/pr9.0000000000000927 Cytokines, Neuropathic pain, Neuroinflammation, content are disclosed at the end of this article., Dieren—Module Kennisinfrastructuur “De praktijk van een Synthesis of Evidence” voor, dierexperimenteel onderzoek) and the Dutch Association for Manual Therapy (NVMT,, grant nr. 2015-10).Sponsorships or competing interests that may be relevant to, in Dutch: Meer Kennis met Minder, Manual therapy, Neural mobilisation, Neurodynamics, Nonpharmacological treatment, with Fewer Animals, (grant nr. 114024120, ZonMw grant synthesis of evidence in practice, within the program More Knowledge