Dietary poultry intake and the risk of stroke: A dose-response meta-analysis of prospective cohort studies

Mohammadi, H. and Jayedi, A. and Ghaedi, E. and Golbidi, D. and Shab-Bidar, S.

Clin Nutr ESPEN (2018) 23: 25–33

DOI: 10.1016/j.clnesp.2017.11.001

Abstract

BACKGROUND & AIMS: We performed a meta-analysis to illuminate and quantify the potential relationship between poultry intake and risk of stroke through summarizing available evidence using a dose-response meta-analysis of prospective cohort studies. METHODS: Pertinent prospective cohort studies attained using electronic searches through PubMed, and Scopus up to September 25th, 2017. Relative risks (RR) s with corresponding 95% confidence intervals (CIs) of the highest versus the lowest for cohort studies were evaluated using DerSimonian and Laird random-effects models to find combined RRs. We also assessed the dose-response effect of this relationship. RESULTS: A total of 7 studies involving 354 718 participants were met inclusion criteria. The pooled RR of total stroke risk was [RR = 0.92 95% CI, 0.82, 1.03, I(2) = 19.8%, P(heterogeneity) = 0.28] for the highest versus lowest categories of poultry intake. Subgroup analysis showed an inverse associations for the US people [RR = 0.86 95% CI, 0.77, 0.95, I(2) = 0.0%, P(heterogeneity) = 0.38] and women [RR = 0.83, 95% CI, 0.72, 0.93, I(2) = 0.0%, P(heterogeneity) = 0.63]. We did not obtain any significant association in the subtypes of strokes with highest versus lowest poultry intake [Ischemic stroke (RR = 0.91; 95% CI: 0.79, 1.02, I(2) = 0.0%, p = 0.93), Hemorrhagic (RR = 0.82; 95% CI: 0.59, 1.04, I(2) = 20.5%, P(heterogeneity) = 0.28)]. One serving per week increment in poultry intake was not associated with the risk of stroke (RR: 1.00, 95% CI: 0.96, 1.03, I(2) = 69.0%, P(heterogeneity) = 0.004). Nonlinear dose-response meta-analysis showed lower risk of stroke at consumption ∼1 serving/week. CONCLUSION: Our meta-analysis revealed that poultry intake is not associated with total stroke risk; furthermore, an inverse relationship in US population and females must be interpreted with caution.

Citation

Mohammadi, H., Jayedi, A., Ghaedi, E., Golbidi, D., & Shab-Bidar, S. (2018). Dietary poultry intake and the risk of stroke: A dose-response meta-analysis of prospective cohort studies. Clin Nutr ESPEN, 23, 25–33. https://doi.org/10.1016/j.clnesp.2017.11.001 Animals, Humans, Risk Factors, United States, *Meta-analysis, Incidence, *Diet, Databases, Factual, *Dose–response, *Poultry, *Poultry intake, *Stroke risk, Stroke/*epidemiology

Keywords

• Animals
• Humans
• Risk Factors
• United States
• *Meta-analysis
• Incidence
• *Diet
• Databases
• Factual
• *Dose–response
• *Poultry
• *Poultry intake
• *Stroke risk
• Stroke/*epidemiology