The use of platelet-rich plasma for treatment of tenodesmic lesions in horses: a systematic review and meta-analysis of clinical and experimental data

Montano, C. and Auletta, L. and Greco, A. and Costanza, D. and Coluccia, P. and Prete, C. del and Meomartino, L. and Pasolini, M. P.

Animals (2021) 11:

DOI: 10.3390/ani11030793

Abstract

The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Outcomes were clinical, ultrasound, histologic, molecular evaluation, and adverse effects. Two authors independently extracted data and assessed each study’s risk of bias. Treatment effects were evaluated using risk ratios for dichotomous data, together with 95% CI. Data were pooled using the random-effects model. The quality of the evidence for each outcome was assessed using GRADE criteria. Twenty-four trials met inclusion criteria for systematic review, while fifteen studies were included in the meta-analysis. Results showed no significant differences in the outcomes between PRP and control groups. Finally, there is no definitive evidence that PRP enhances tendons and ligaments healing. Therefore, there is a need for more controlled trials to draw a firmer conclusion about the efficacy of PRP as a treatment for tenodesmic lesions in the horse.

Citation

Montano, C., Auletta, L., Greco, A., Costanza, D., Coluccia, P., Prete, C. del, Meomartino, L., & Pasolini, M. P. (2021). The use of platelet-rich plasma for treatment of tenodesmic lesions in horses: a systematic review and meta-analysis of clinical and experimental data. Animals, 11(3). https://doi.org/10.3390/ani11030793 platelets, plasma, Horses, meta-analysis, effects, Equus, horses, systematic reviews, therapeutics, therapy, Animal Surgery and Non-drug Therapy [LL884], blood plasma, blood platelets, ligaments, Non-communicable Diseases and Injuries of Animals [LL860], plasma (blood), tendons, thrombocytes, data analysis, guidelines, recommendations, lesions, evaluation, adverse effects, trauma, efficacy, healing, Sport Animals [LL075], adverse reactions, quality, ultrasound, Blood Platelets, traumas, Diagnostic, Therapeutic and Pharmacological Biotechnology [WW700], placebos, platelet rich plasma

Keywords

• platelets
• plasma
• Horses
• meta-analysis
• effects
• Equus
• horses
• systematic reviews
• therapeutics
• therapy
• Animal Surgery and Non-drug Therapy [LL884]
• blood plasma
• blood platelets
• ligaments
• Non-communicable Diseases and Injuries of Animals [LL860]
• plasma (blood)
• tendons
• thrombocytes
• data analysis
• guidelines
• recommendations
• lesions
• evaluation
• adverse effects
• trauma
• efficacy
• healing
• Sport Animals [LL075]
• adverse reactions
• quality
• ultrasound
• Blood Platelets
• traumas
• Diagnostic
• Therapeutic and Pharmacological Biotechnology [WW700]
• placebos
• platelet rich plasma