Effectiveness of phytotherapeutics in the prevention and treatment of 5-fluorouracil-induced oral mucositis in animal models: a systematic review

Morais, E. F. de and Batista Severo, M. L. and Dantas Martins, H. D. and Trevizani Martins, M. A. and Martins, M. D. and Almeida Freitas, R. de and Silveira, E. J. D. da

Archives of Oral Biology (2021) 123: 123

DOI: 10.1016/j.archoralbio.2020.104998

Abstract

Objectives: This systematic review evaluated the effect of phytotherapeutics in the treatment and prevention of 5-fluorouracil (5-FU)-induced oral mucositis (OM) in animal models. Design: A search was performed in PubMed/Medline, CENTRAL (The Cochrane Library), EMBASE, and Web of Science, including studies published up to January 2020. Only articles investigating the chemoinduction of OM by 5-FU in animal models were included. Eligibility was evaluated and data were extracted from the eligible studies following the predefined PICO questions. The Cochrane Collaboration Risk of Bias Assessment tool was used to evaluate the quality of the included studies. Result: A total of 503 articles were retrieved and 13 were included. The hamster was the animal model used in all included studies. The treatment method ranged from the topical application of ointment (n = 3), gel (n = 5) and extract (n = 3) to the oral ingestion of the phytotherapeutics (n = 3). Chamomilla recutita L. (n = 3) and Pistacia atlantica (n = 3) were the most used therapeutic agents. Although all studies were classified as high risk of bias, all of them reported promising results regarding the use of phytotherapeutics in the management of OM, including lower clinical and histopathological scores as well as healing, anti-inflammatory, antimicrobial, and antioxidant activities.

Citation

Morais, E. F. de, Batista Severo, M. L., Dantas Martins, H. D., Trevizani Martins, M. A., Martins, M. D., Almeida Freitas, R. de, & Silveira, E. J. D. da. (2021). Effectiveness of phytotherapeutics in the prevention and treatment of 5-fluorouracil-induced oral mucositis in animal models: a systematic review. Archives of Oral Biology, 123, 123. https://doi.org/10.1016/j.archoralbio.2020.104998 inflammation, animal models, effects, systematic reviews, plants, medicinal plants, antiinflammatory properties, antioxidant properties, efficacy, topical application, Animal and in vitro Models for Pharmaceuticals [VV450], Animal Models of Human Diseases [VV400], drug plants, medicinal herbs, officinal plants, Non-food/Non-feed Plant Products [SS200], anti-inflammatory properties, anti-oxidant properties, extracts, radical scavenging properties, chamomile, Chamomilla recutita, ointments, Pistacia atlantica, wild relatives

Keywords

• inflammation
• animal models
• effects
• systematic reviews
• plants
• medicinal plants
• antiinflammatory properties
• antioxidant properties
• efficacy
• topical application
• Animal and in vitro Models for Pharmaceuticals [VV450]
• Animal Models of Human Diseases [VV400]
• drug plants
• medicinal herbs
• officinal plants
• Non-food/Non-feed Plant Products [SS200]
• anti-inflammatory properties
• anti-oxidant properties
• extracts
• radical scavenging properties
• chamomile
• Chamomilla recutita
• ointments
• Pistacia atlantica
• wild relatives