Studying the relationship of intermittent fasting and beta-amyloid in animal model of Alzheimer’s disease: a scoping review

Muhammad Luqman, Nasaruddin and Abd Halim, S. A. S. and Mohd Amir, Kamaruzzaman

Nutrients (2020) 12:

DOI: 10.3390/nu12103215

Abstract

We examined the evidence for intermittent fasting (IF) as a preventative tool to influence beta-amyloid in animal models of Alzheimer’s disease (AD). A Scopus, Ovid, PubMed, and Web of Science (WoS), search yielded 29 results using the keywords "amyloid beta", "intermittent fasting", "intermittent caloric restriction", "alternate day fasting", "modified alternate-day fasting", "time-restricted feeding", "Ramadan fast", "intermittent calori* restriction", "intermittent restrictive diet", and "Alzheimer*". Five research articles addressed directly the effects of intermittent fasting on beta-amyloid levels in animal models of AD: alternate day fasting (ADF) and time-restricted feeding (TRF) methods were incorporated in these studies. The study designs were found to be heterogeneous. Variations in the levels of beta-amyloid peptides or plaque in either the hippocampus, cortical areas, or both in animals following dietary intervention were observed as compared to the ad libitum group. Non-significant changes were observed in three studies, while two studies interestingly demonstrated amelioration and reduction in beta-amyloid levels. Given the conflicting results obtained from this study, significant care has to be taken into consideration before the protocol can be applied as a preventative approach to treat Alzheimer’s disease. Longitudinal research is warranted to fully grasp how dietary habits can help alleviate the disease either through upstream or downstream of AD pathology.

Citation

Muhammad Luqman, N., Abd Halim, S. A. S., & Mohd Amir, K. (2020). Studying the relationship of intermittent fasting and beta-amyloid in animal model of Alzheimer’s disease: a scoping review. Nutrients, 12(10). https://doi.org/10.3390/nu12103215 animals, animal models, effects, man, diets, research, studies, feeding, models, human diseases, laboratory animals, animal feeding, energy deprivation, feeding habits, disease models, hippocampus, Non-communicable Human Diseases and Injuries [VV600], Animal Models of Human Diseases [VV400], Alzheimer’s disease, peptides, brain, cerebrum, Animal Models of Human Nutrition [VV140], amyloids, eating habits, eating patterns, fasting, restricted feeding

Keywords

• animals
• animal models
• effects
• man
• diets
• research
• studies
• feeding
• models
• human diseases
• laboratory animals
• animal feeding
• energy deprivation
• feeding habits
• disease models
• hippocampus
• Non-communicable Human Diseases and Injuries [VV600]
• Animal Models of Human Diseases [VV400]
• Alzheimer’s disease
• peptides
• brain
• cerebrum
• Animal Models of Human Nutrition [VV140]
• amyloids
• eating habits
• eating patterns
• fasting
• restricted feeding