Do high levels of maternally derived antibodies interfere with the vaccination of piglets against porcine circovirus type 2? A literature review and data analysis

Nautrup, B. P. and Vlaenderen, I. van and Mah, ChoewKong and Angulo, J.

Vaccines (2021) 9:

DOI: 10.3390/vaccines9080923

Abstract

Vaccination against porcine circovirus type 2 (PCV2) is commonly performed in piglets worldwide, and increasingly also in sows. We conducted a literature search and review to assess the potential interference of maternally derived antibodies (MDA) in piglets with vaccination against PCV2. The effectiveness of vaccination was compared to no vaccination in the presence of high levels of MDA (8 log_\textrm2 IPMA titer), as reported in field studies. In total, 13 papers fulfilled the predefined inclusion criteria, allowing up to 24 comparisons per parameter. In the presence of high levels of MDA, vaccinated pigs had, on average, a 20 g/d higher mean daily weight gain and a 34% lower mortality compared to non-vaccinates. The maximum percentage of viremic pigs was reduced by 63% and the maximum viral load in serum was 0.72 log_\textrm10 PCV2 DNA copies lower. Vaccination at 3 weeks of age was associated with the highest improvements in production parameters and reductions in viremia. Our findings suggest that the vaccination of piglets is effective with respect to production parameters and viremia even in the presence of high MDA, with an age of 3 weeks at vaccination being most beneficial.

Citation

Nautrup, B. P., Vlaenderen, I. van, Mah, C. K., & Angulo, J. (2021). Do high levels of maternally derived antibodies interfere with the vaccination of piglets against porcine circovirus type 2? A literature review and data analysis. Vaccines, 9(8). https://doi.org/10.3390/vaccines9080923 pregnancy, immune system, Animal Reproduction and Embryology [LL250], gestation, hogs, pigs, sows, swine, Host Resistance and Immunity [HH600], meta-analysis, vaccination, vaccines, liveweight gain, liveweight gains, mortality, Mathematics and Statistics [ZZ100], Meat Producing Animals [LL120], Animal Behaviour [LL300], literature reviews, death rate, viral diseases, blood serum, immunity, efficacy, immune response, immunity reactions, immunological reactions, potency, piglets, antibodies, Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821], viral infections, Porcine circovirus-2, maternal antibodies, employees of Zoetis., immunological parameters, maternally derived antibodies, porcine circovirus type 2, production parameters, viremia, were paid external consultants to Zoetis. ChoewKong Mah and Jose Angulo are

Keywords

• pregnancy
• immune system
• Animal Reproduction and Embryology [LL250]
• gestation
• hogs
• pigs
• sows
• swine
• Host Resistance and Immunity [HH600]
• meta-analysis
• vaccination
• vaccines
• liveweight gain
• liveweight gains
• mortality
• Mathematics and Statistics [ZZ100]
• Meat Producing Animals [LL120]
• Animal Behaviour [LL300]
• literature reviews
• death rate
• viral diseases
• blood serum
• immunity
• efficacy
• immune response
• immunity reactions
• immunological reactions
• potency
• piglets
• antibodies
• Prion
• Viral
• Bacterial and Fungal Pathogens of Animals [LL821]
• viral infections
• Porcine circovirus-2
• maternal antibodies
• employees of Zoetis.
• immunological parameters
• maternally derived antibodies
• porcine circovirus type 2
• production parameters
• viremia
• were paid external consultants to Zoetis. ChoewKong Mah and Jose Angulo are