A Systematic Review of Rat Models With Temporomandibular Osteoarthritis Suitable for the Study of Emerging Prolonged Intra-Articular Drug Delivery Systems.

Nicot R and Barry F and Chijcheapaza-Flores H and Garcia-Fernandez MJ and Raoul G and Blanchemain N and Chai F

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (2021) 79: 1650–1671

DOI: 10.1016/j.joms.2021.02.034

Abstract

PURPOSE: Development of minimally invasive therapies for temporomandibular joint osteoarthritis (TMJOA) has focused on drug intra-articular injections to avoid the systemic adverse effects experienced when these substances are administered orally. Therefore, we performed a systematic review to answer the question "Which method of induction of a TMJOA-related pain model in rats leads to prolonged painful symptoms, allowing the best assessment of a sustained drug delivery system?" MATERIALS AND METHODS: Following the PRISMA guidelines, we searched MEDLINE for papers published from 1994 to July 2020 on a TMJ arthritis model using rats. We identified the means of pain induction and of nociception assessment. We assessed protocol bias using an adaptation of the QUADAS-2 tool. Animal selection, the reference standard method of pain assessment, applicability of a statistical assessment, and flow and timing were assessed. RESULTS: Of the 59 full papers we reviewed, 41 performed no pain assessment after the first 7 days following induction of the TMJ-related pain model. We eventually identified 18 long-term TMJOA-related pain models. Pain was induced by injection of toxic substances, most commonly Freund’s complete adjuvant (50 μg per 50 μl), formalin at various concentrations, or monosodium iodoacetate (0,5 mg per 50 μl), into the TMJ, or by physical methods. Few studies reported data on pain after 21 days of follow-up. Heterogeneity of induction methods, pain assessment methods, and flow and timing biases precluded a meta-analysis. CONCLUSIONS: Given that pain is 1 of the main symptoms of TMJOA, experimental study protocols should include long-term pain assessment.

Citation

Nicot R, Barry F, Chijcheapaza-Flores H, Garcia-Fernandez MJ, Raoul G, Blanchemain N, & Chai F. (2021). A Systematic Review of Rat Models With Temporomandibular Osteoarthritis Suitable for the Study of Emerging Prolonged Intra-Articular Drug Delivery Systems. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons, 79(8), 1650–1671. https://doi.org/10.1016/j.joms.2021.02.034 Animals, Rats, Osteoarthritis, Drug Delivery Systems, Injections, Intra-Articular, Temporomandibular Joint, *Osteoarthritis/drug therapy, *Temporomandibular Joint Disorders/drug therapy

Keywords

• Animals
• Rats
• Osteoarthritis
• Drug Delivery Systems
• Injections
• Intra-Articular
• Temporomandibular Joint
• *Osteoarthritis/drug therapy
• *Temporomandibular Joint Disorders/drug therapy