A systematic review and network meta-analysis of bacterial and viral vaccines, administered at or near arrival at the feedlot, for control of bovine respiratory disease in beef cattle

O’Connor, A. M. and Hu, D. and Totton, S. C. and Scott, N. and Winder, C. B. and Wang, B. and Wang, C. and Glanville, J. and Wood, H. and White, B. and Larson, R. and Waldner, C. and Sargeant, J. M.

Anim Health Res Rev (2019) 20: 143–162

DOI: 10.1017/s1466252319000288

Abstract

Vaccination against putative causal organisms is a frequently used and preferred approach to controlling bovine respiratory disease complex (BRD) because it reduces the need for antibiotic use. Because approximately 90% of feedlots use and 90% of beef cattle receive vaccines in the USA, information about their comparative efficacy would be useful for selecting a vaccine. We conducted a systematic review and network meta-analysis of studies assessing the comparative efficacy of vaccines to control BRD when administered to beef cattle at or near their arrival at the feedlot. We searched MEDLINE, MEDLINE In-Process, MEDLINE Daily Epub Ahead of Print, AGRICOLA, Cambridge Agricultural and Biological Index, Science Citation Index, and Conference Proceedings Citation Index - Science and hand-searched the conference proceedings of the American Association of Bovine Practitioners and World Buiatrics Congress. We found 53 studies that reported BRD morbidity within 45 days of feedlot arrival. The largest connected network of studies, which involved 17 vaccine protocols from 14 studies, was included in the meta-analysis. Consistent with previous reviews, we found little compelling evidence that vaccines used at or near arrival at the feedlot reduce the incidence of BRD diagnosis.

Citation

O’Connor, A. M., Hu, D., Totton, S. C., Scott, N., Winder, C. B., Wang, B., Wang, C., Glanville, J., Wood, H., White, B., Larson, R., Waldner, C., & Sargeant, J. M. (2019). A systematic review and network meta-analysis of bacterial and viral vaccines, administered at or near arrival at the feedlot, for control of bovine respiratory disease in beef cattle. Anim Health Res Rev, 20(2), 143–162. https://doi.org/10.1017/s1466252319000288 Animals, Cattle, *systematic review, *meta-analysis, Network Meta-Analysis, Cattle Diseases/*prevention & control, *respiratory disease, *Bovine, *vaccination, Bacterial Vaccines/administration & dosage/*immunology, Respiratory Tract Diseases/prevention & control/*veterinary, Viral Vaccines/administration & dosage/*immunology

Keywords

• Animals
• Cattle
• *systematic review
• *meta-analysis
• Network Meta-Analysis
• Cattle Diseases/*prevention & control
• *respiratory disease
• *Bovine
• *vaccination
• Bacterial Vaccines/administration & dosage/*immunology
• Respiratory Tract Diseases/prevention & control/*veterinary
• Viral Vaccines/administration & dosage/*immunology