A systematic review and network meta-analysis of injectable antibiotic options for the control of bovine respiratory disease in the first 45 days post arrival at the feedlot

O’Connor, A. M. and Hu, D. and Totton, S. C. and Scott, N. and Winder, C. B. and Wang, B. and Wang, C. and Glanville, J. and Wood, H. and White, B. and Larson, R. and Waldner, C. and Sargeant, J. M.

Anim Health Res Rev (2019) 20: 163–181

DOI: 10.1017/s1466252320000031

Abstract

We conducted a systematic review and network meta-analysis to determine the comparative efficacy of antibiotics used to control bovine respiratory disease (BRD) in beef cattle on feedlots. The information sources for the review were: MEDLINE®, MEDLINE In-Process and MEDLINE® Daily, AGRICOLA, Epub Ahead of Print, Cambridge Agricultural and Biological Index, Science Citation Index, Conference Proceedings Citation Index - Science, the Proceedings of the American Association of Bovine Practitioners, World Buiatrics Conference, and the United States Food and Drug Administration Freedom of Information New Animal Drug Applications summaries. The eligible population was weaned beef cattle raised in intensive systems. The interventions of interest were injectable antibiotics used at the time the cattle arrived at the feedlot. The outcome of interest was the diagnosis of BRD within 45 days of arrival at the feedlot. The network meta-analysis included data from 46 studies and 167 study arms identified in the review. The results suggest that macrolides are the most effective antibiotics for the reduction of BRD incidence. Injectable oxytetracycline effectively controlled BRD compared with no antibiotics; however, it was less effective than macrolide treatment. Because oxytetracycline is already commonly used to prevent, control, and treat BRD in groups of feedlot cattle, the use of injectable oxytetracycline for BRD control might have advantages from an antibiotic stewardship perspective.

Citation

O’Connor, A. M., Hu, D., Totton, S. C., Scott, N., Winder, C. B., Wang, B., Wang, C., Glanville, J., Wood, H., White, B., Larson, R., Waldner, C., & Sargeant, J. M. (2019). A systematic review and network meta-analysis of injectable antibiotic options for the control of bovine respiratory disease in the first 45 days post arrival at the feedlot. Anim Health Res Rev, 20(2), 163–181. https://doi.org/10.1017/s1466252320000031 *Antibiotics, *bovine, *meta-analysis, *Network Meta-Analysis, *respiratory disease, *systematic review, Animals, Anti-Bacterial Agents/*administration & dosage/therapeutic use, antibiotics, Bovine Respiratory Disease Complex/*prevention & control, Cattle, chemotherapy, Control [HH405], drug resistance, drug susceptibility, drug therapy, enrofloxacin, fluoroquinolone antibiotics, gamithromycin, hogs, injectable antibiotics, lung diseases, marbofloxacin, meta-analysis, Pesticide and Drug Resistance [HH410], Pesticides and Drugs, pigs, prescriptions, Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821], respiratory diseases, swine, United States

Keywords

• *Antibiotics
• *bovine
• *meta-analysis
• *Network Meta-Analysis
• *respiratory disease
• *systematic review
• Animals
• Anti-Bacterial Agents/*administration & dosage/therapeutic use
• antibiotics
• Bovine Respiratory Disease Complex/*prevention & control
• Cattle
• chemotherapy
• Control [HH405]
• drug resistance
• drug susceptibility
• drug therapy
• enrofloxacin
• fluoroquinolone antibiotics
• gamithromycin
• hogs
• injectable antibiotics
• lung diseases
• marbofloxacin
• meta-analysis
• Pesticide and Drug Resistance [HH410]
• Pesticides and Drugs
• pigs
• prescriptions
• Prion
• Viral
• Bacterial and Fungal Pathogens of Animals [LL821]
• respiratory diseases
• swine
• United States