Activation of Brown Adipose Tissue and Promotion of White Adipose Tissue Browning by Plant-based Dietary Components in Rodents: A Systematic Review

Osuna-Prieto, FJ and Martinez-Tellez, B and Segura-Carretero, A and Ruiz, JR

Advances in nutrition (Bethesda, Md.) (2021) 12: 2147–2156

DOI: 10.1093/advances/nmab084

Abstract

Activation of brown adipose tissue (BAT) and promotion of white adipose tissue (WAT) browning is considered a potential tool to combat obesity and cardiometabolic disorders. The use of plant-based dietary components has become one of the most used strategies for activating BAT and promoting WAT browning in rodents. The main reason is because plant-based dietary components are usually recognized as safe when the dose is properly adjusted, and they can easily be administrated by being added to the diet or dissolved in water. The present systematic review aimed to study the effects of plant-based dietary components on activation of BAT and promotion of WAT browning in rodents. A systematic search of PubMed and Scopus (from 1978 to 2019) identified eligible studies. Studies assessing the effects of plant-based dietary components added to diet and/or water on uncoupling protein 1 (UCP1) expression in BAT and/or WAT were included. Studies that used dietary components of animal origin, did not specify the effects on UCP1, or were conducted in other species different from mice or rats were excluded. Of 3919 studies identified in the initial screening, 146 studies were finally included in the review. We found that tea extract catechins, resveratrol, capsaicin and capsinoids, cacao extract flavanols, and quercetin were the most studied components. Scientific evidence suggests that some of these dietary components activate BAT and promote WAT browning via activation of the AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) pathways. These findings reveal that there is strong scientific evidence supporting the use of plant-based dietary components to activate BAT and promote WAT browning in rodents and thus to potentially combat obesity and cardiometabolic disorders.

Citation

Osuna-Prieto, F. J., Martinez-Tellez, B., Segura-Carretero, A., & Ruiz, J. R. (2021). Activation of Brown Adipose Tissue and Promotion of White Adipose Tissue Browning by Plant-based Dietary Components in Rodents: A Systematic Review. Advances in Nutrition (Bethesda, Md.), 12(6), 2147–2156. https://doi.org/10.1093/advances/nmab084 Animals, Rats, Humans, Mice, Diet, Adipose Tissue, Rodentia, *Adipose Tissue, Brown, *Thermogenesis, Adipose Tissue, White

Keywords

• Animals
• Rats
• Humans
• Mice
• Diet
• Adipose Tissue
• Rodentia
• *Adipose Tissue
• Brown
• *Thermogenesis
• Adipose Tissue
• White