Effects of astaxanthin in animal models of obesity-associated diseases: a systematic review and meta-analysis

Radice, R. P. and Limongi, A. R. and Viviano, E. and Padula, M. C. and Martelli, G. and Bermano, G.

Free Radical Biology & Medicine (2021) 171: 156–168

DOI: 10.1016/j.freeradbiomed.2021.05.008

Abstract

Background and aim: Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The use of natural products, such as astaxanthin (ASX), a potent antioxidant compound produced by the freshwater green microalga Haematococcus pluvialis, has gained particular interest to reduce oxidative stress and inflammation, and to improve redox status, often associated with obesity. A systematic review and meta-analysis was performed to comprehensively examine the effects of ASX in animal models of diet induced obesity-associated diseases in order to inform the design of future human clinical studies for ASX use as supplement or nutraceutical.

Citation

Radice, R. P., Limongi, A. R., Viviano, E., Padula, M. C., Martelli, G., & Bermano, G. (2021). Effects of astaxanthin in animal models of obesity-associated diseases: a systematic review and meta-analysis. Free Radical Biology & Medicine, 171, 156–168. https://doi.org/10.1016/j.freeradbiomed.2021.05.008 non-alcoholic fatty liver disease, obesity, liver, inflammation, meta-analysis, animal models, effects, systematic reviews, body weight, risk factors, laboratory animals, disease models, liver diseases, metabolic syndrome, blood sugar, diabetes mellitus, type 2 diabetes, antioxidants, quantitative analysis, Non-communicable Human Diseases and Injuries [VV600], Animal Models of Human Diseases [VV400], fatness, Animal Models of Human Nutrition [VV140], blood glucose, glucose in blood, body mass index, overweight, astaxanthin, Haematococcus pluvialis, microalgae

Keywords

• non-alcoholic fatty liver disease
• obesity
• liver
• inflammation
• meta-analysis
• animal models
• effects
• systematic reviews
• body weight
• risk factors
• laboratory animals
• disease models
• liver diseases
• metabolic syndrome
• blood sugar
• diabetes mellitus
• type 2 diabetes
• antioxidants
• quantitative analysis
• Non-communicable Human Diseases and Injuries [VV600]
• Animal Models of Human Diseases [VV400]
• fatness
• Animal Models of Human Nutrition [VV140]
• blood glucose
• glucose in blood
• body mass index
• overweight
• astaxanthin
• Haematococcus pluvialis
• microalgae